葛根注射液抗心肌缺血的药理作用研究  

Pharmacological study on anti-myocardial ischemia effect of gegen injection in rat isolated heart

作　　者：郜清[1] 顾燕 

机构地区：[1]江苏省中医院,江苏南京210029 [2]江苏睿博医药有限公司,江苏南京211112

出　　处：《安徽医药》2017年第1期19-23,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的考察葛根注射液的抗心肌缺血作用。方法考察葛根注射液高中低剂量组对大鼠离体心脏左室峰压(LVSP)、冠脉流量(CF)及大鼠离体心脏缺血再灌注后的LVSP、左室舒张期末压(LVEDP)、心率(HR)、CF的影响。结果葛根注射液可升高大鼠离体心脏心肌收缩力及冠脉流量;对离体心脏缺血再灌注导致的LVSP和LVEDP的升高、心率及冠脉流量的降低均有对抗作用。结论葛根注射液具有抗心肌缺血的作用。Objective To investigate the anti-myocardial ischemia effect of Gegen injection in rat. Methods Determine the effect of Gegen injection in high,medium and low dose on the left ventricular peak voltage（ LVSP）,coronary flow（ CF） of rat isolated heart and LVSP,left ventricular end diastolic pressure（ LVEDP）,heart rate（ HR）,CF of rat isolated heart with ischemia and reperfusion. Results Gegen injection can increase the myocardial contractility and coronary flow in isolated heart of rats. Gegen injection had the effect on the increase of LVEDP,LVSP,HR and CF in isolated heart ischemia reperfusion injury. Conclusion Gegen injection has the effect of anti-myocardial ischemia in rat isolated heart.

关 键 词：葛根注射液 大鼠 离体 抗心肌缺血 

分 类 号：R285.5[医药卫生—中药学]