气相色谱法测定爽肤洗液中薄荷酮和薄荷脑的含量  

Determination of menthone and menthol in toning lotion by GC method

作　　者：葛少波[1] 蒋志涛 雷飞飞 张杰[1] 施务务[1] 

机构地区：[1]蚌埠市第一人民医院药剂科,安徽蚌埠233000 [2]张家港市中医医院江苏省企业研究生工作站,江苏张家港215600

出　　处：《安徽医药》2017年第1期57-59,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省蚌埠市科技发展指导性项目(20160315)

摘　　要：目的建立爽肤洗液中薄荷酮和薄荷脑含量测定的方法。方法采用气相色谱法测定爽肤洗液中薄荷酮和薄荷脑的含量,色谱柱:Agilent DB-WAX毛细管柱(30 m×0.32 mm,0.5μm);程序升温。进样口温度:220℃;检测器:FID,温度为250℃。结果 (-)-薄荷酮和薄荷脑分别在0.049 08~0.981 6、0.044 9~0.898 0μg范围内呈较好的线性关系,r分别为0.999 1、0.999 5,均精密度RSD<1.0%,平均加样回收率分别为98.76%、99.60%,RSD分别为2.25%、1.96%。结论该实验建立的方法易操作,重现性好,可以用来同时测定爽肤洗液中薄荷酮和薄荷脑的含量。Objective To establish a method for the determination of menthone and menthol in Toning lotion. Methods Gas chromatographic（ GC） method was used to determine menthone and menthol content in Toning lotion. Column： Agilent DB-WAX Capillary Column（ 30 m × 0. 32 mm,0. 5 μm）; programmed temperature. The temperature of injection port was 260 ℃,and detector temperature was280 ℃,the detector was FID. Result Good linear correlation for menthone and menthol were found respectively in the range of0. 049 08 ～ 0. 981 6 μg（ r = 0. 999 1） and 0. 044 9 ～ 0. 898 0 μg（ r = 0. 999 5）,the average recoveries of the 2 constituents were98. 76% and 99. 60%,with RSDs of 2. 25% and 1. 96%. Conclusion The established method is accurate,easy to operate and with good reproducibility,which can be used for the determination of menthone and menthol content in Toning lotion.

关 键 词：爽肤洗液 气相色谱法 (-)-薄荷酮 薄荷脑 

分 类 号：R286.0[医药卫生—中药学] O657.71[医药卫生—中医学]