绝经后女性乳腺增生运用芳香化酶抑制剂治疗的分析  

Analysis of Application of Arimedex Treatment for Post-menopause Female Mammary Gland

作　　者：岳雁鸿[1] 曾燕[1] 郑华芳[1] 

机构地区：[1]眉山市中医医院乳腺科,四川眉山620010

出　　处：《中外医疗》2017年第3期1-3,共3页China & Foreign Medical Treatment

摘　　要：目的探讨应用芳香化酶抑制剂治疗绝经后乳腺增生的临床应用效果,分析其临床应用价值。方法整群选取2014年3月—2016年3月期间在该院接诊的142例女性绝经后乳腺增生患者,根据临床治疗方法不同,将其分为观察组(n=71,采用芳香化酶抑制剂治疗)和对照组(n=71,采用他莫昔芬治疗),服药后3个月给予患者复查,了解患者的增生临床症状,观察患者的不良反应,对组间临床疗效进行对比,对其数据进行统计学处理。结果在接受不同治疗情况下,观察组患者左侧乳腺导管为(0.06±0.02),对照组为(0.13±0.07),观察组患者右侧乳腺导管为(0.07±0.03),对照组为(0.14±0.06),观察组患者乳腺纹理增粗左侧发生率为94.36%,右侧为95.77%,对照组患者乳腺纹理增粗左侧发生率为52.11%,右侧为54.92%,比较差异有统计学意义(P<0.05);观察组患者上呼吸道感染发生率为2.81%,盗汗发生率为1.41%,疼痛发生率为2.81%,对照组分别为18.31%,12.67%,21.12%,对比差异有统计学意义(P<0.05)。结论在当前女性绝经乳腺增生患者临床治疗过程中,采用芳香化酶抑制剂治疗属于理想的治疗方法,有效改善患者增生症状,安全性高,不良反应少,值得临床推广和应用。Objective To d iscu ss th e c l in ic a l ap p l ic a t io n effect of a r im edex trea tm en t for p o s t-me n o p a u s e female mammary gland and analyze the cl inical appl icat ion value. Methods 142 c a se s of female p a t ien ts with p o s t -m e n o p a u s e mammary gland treated in our hospi tal from March 2014 to March 2016 were group selected and divided into two groups with 71 cas-es in each according to different cl inical treatment methods, the observation, the observation group were treated with ar imedex, while the control group were treated with tamoxifen, and the patients were reviewed in 3 months af ter medicat ion, and the cl inical symptom of hyperplasia of pat ients were known, and the adverse reactions of pat ients were observed and the cl inical curat ive effect of pat ients was compared, and the data were stat is t ically processed. Results After trea tm en t, th e left and right mammary gland duct was （0.06±0.02） and （0.07±0.03） in the observation group and （0.13±0.07） and （0.14±0.06） in the control group, and the difference in the left and right breast texture thickening in the observation group had stat is t ical signif icance（94.36%, 95.77%）, and the difference in the left and right breast texture thickening in the control group had sta-t is t ical signif icance（52.11%, 54.92%） , and the difference had stat is t ical signif icance （P〈0.05）, and the differences in the in-cidence rates of upper respiratory tract infect ion, night sweat and pains between the observation group and the control group had stat ist ical signif icance by compar ison,（2.81%, 1 .4 1%, 2 .8 1% vs 1 8 .3 1%, 1 2 .6 7%, 2 1 .1 2% ） ,th e d ifferenc e was s tat ist ic ally s ignif icant（P〈0.05） . Conclusion In th e c l in ic a l tre a tm en t co u rse, th e a r im edex tre a tm en t is an id e a l metho d , which c an ef-fect ively improve the hyperplasia symptoms of pat ients with high safety and few a

关 键 词：绝经 女性 乳腺增生 芳香化酶抑制剂 疗效 观察 

分 类 号：R5[医药卫生—内科学]