新生儿凝血试验参考范围相关研究进展  

Related Research Progress of Thrombotest Reference Range in Newborns

作　　者：刘珍[1] 王晓明[1] 

机构地区：[1]复旦大学附属上海市第五人民医院儿科,上海200240

出　　处：《中外医疗》2017年第3期194-198,共5页China & Foreign Medical Treatment

摘　　要：人类凝血系统是一个复杂的动态平衡的系统,这对于维持健康的生活至关重要的。在西方国家,由于凝血系统的波动所致非传染性疾病的发病率和死亡率均较高。现在清楚的是,3~6个月龄的婴儿凝血系统尚未完全成熟,新生儿及儿童生理性凝血与成年人也有所不同,有研究证实了这些差异可能是一种自然的生理性保护机制。临床上,足月儿和早产儿(胎龄30~36周)刚出生时凝血试验使用同一参考范围。超早产儿(尤其是胎龄<27周)止凝血方面的数据十分稀缺。尚无完整统一的新生儿生后的凝血试验参考范围,因此大大限制止凝血功能正常与否的判断,以及对实验室凝血检查结果异常是否可以指导临床采取干预措施带来极大的困扰。国内新生儿凝血试验参考范围相关研究几乎空白,该综述目的是总结国外对新生儿凝血系统及新生儿年龄相关性凝血参考范围的认识,同时也对新生儿凝血试验的解读进行了综述。The h uman coagula tion system is a complex, dynamic an d b a la n c ed system, which is v ita l to m a in ta in in g the healthy l ife, in wes te rn co u ntry, th e morbidity ra te an d d e a th ra te of n o n - in fe c t io u s d ise a se s d u e to th e fluc tu ate s of co agu-lation system are h ig h, an d it is cle a r ly th a t th e coagula tion system of infants aged from 3 months to 6 months is not com-pletely ma tu re, and th e p h y s ic a l coagula tion in newborns and c h i ld ren is different from th a t of a d u l ts, an d some re se arch es proves th a t th e s e differenc es maybe a n a tu ra l p hy sica l p ro tec tiv e m echan ism , in c l in ic, th e coagula tion te s t of fu l l - te rm in -fant and p rema tu re baby （the g e s tat io na l age was from 30 weeks to 36 w eeks） u sed th e same ra n g e, th e d a ta of h em o s ta s is- coagulation of su p e r p reterm in fa n ts, which greatly limits th e ju d gm en t of h em o s ta s is -co ag u la t io n fu n c t io n , and th e re la ted research of thrombote st re fe ren c e range in newborns a t home is b la n k , an d the p urpo se of th e p ap e r is to summarize the awareness of coagula tion system in newborns ab road an d re la ted coagulation re fe ren ce range an d e lab orates th e coagulation tes t in n ewb orn s.

关 键 词：新生儿 凝血试验 参考范围 

分 类 号：R446[医药卫生—诊断学]