气道重塑与磷脂酰肌醇3激酶/蛋白激酶B信号通路在支气管哮喘发病机制中的研究进展  

Recent advances in the study of airway remodeling and PI3K/PKB signaling pathway in the pathogenesis of bronchial asthma

作　　者：潘凌宇[1,2] 韩燕全[2] 柳清[1] 桂洁[2] 汪永忠[2] 

机构地区：[1]安徽中医药大学,安徽合肥230012 [2]安徽中医药大学第一附属医院,国家中医药管理局制剂三级实验室,安徽合肥230031

出　　处：《安徽医药》2016年第12期2214-2218,共5页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省高等学校自然科学研究项目(KJ2015A124);安徽省卫生计生委中医药科研课题(2016ZY03);安徽中医药大学科研基金(2015qn020)

摘　　要：支气管哮喘是一种以可逆性气流受限为特征的气道慢性炎症性疾病。在支气管哮喘众多发病机制中,气道重塑与磷脂酰肌醇3激酶/蛋白激酶B(PI3K/PKB)通路联系紧密。气道重塑与支气管气道平滑肌细胞的增殖和凋亡密切相关。PI3K/PKB信号通路作为细胞内一条重要的信号传导通路,起到抑制细胞凋亡、促进细胞周期的进展,介导细胞增殖等作用,因而可以结合气道重塑与PI3K/PKB通路对支气管哮喘的发病和治疗进行探讨和研究。该研究现对支气管哮喘、气道重塑、PI3K/PKB通路的研究进展进行了综述,以期为支气管哮喘的治疗提供借鉴。Bronchial asthma is a chronic airway inflammatory disease characterized by reversible airflow limitation.In the pathogenesis of bronchial asthma,airway remodeling is closely related to the PI3K/PKB pathway.And the airway remodeling is closely related to the proliferation and apoptosis of bronchial airway smooth muscle cells.As an important signal transduction pathway,PI3K/PKB signaling pathway plays an important role in inhibiting cell apoptosis,promoting cell cycle progression,mediating cell proliferation and so on.So it can be combined with airway remodeling and PI3K/PKB pathway for the exploration and study of the pathogenesis and treatment of bronchial asthma.This review focuses on advances in bronchial asthma,airway remodeling and PI3K/PKB pathway.

关 键 词：支气管哮喘 气道重塑 磷脂酰肌醇3激酶/蛋白激酶B通路 

分 类 号：R562.25[医药卫生—呼吸系统]