急性心肌缺血模型的11C－甲基多巴胺心脏受体显像  

Cardiac neuroceptor imaging on acute myocardial ischemia model using 11C-methyldopamine

作　　者：周伟娜[1] 何玉林[1] 王相成[1] 张国建[1] 白侠[1] 郝喜燕[1] 王雪梅[1] 

机构地区：[1]内蒙古医科大学附属医院PET/CT中心,呼和浩特010050

出　　处：《中华核医学与分子影像杂志》2017年第5期265-268,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金（81460271,81560686,81660295）;内蒙古自治区自然科学基金[2012ZD11,2016MS（LH）0812];内蒙古自治区卫生厅基金（201302069）

摘　　要：目的应用心脏交感神经突触前分子探针11C－MDA对巴马小型猪急性心肌缺血模型进行研究，并与13N－Ammonia心肌血流灌注显像进行对比。方法选取12只巴马小型猪制备急性心肌缺血模型。分别于造模前，造模后1 d及1、3、6个月行11C－MDA和13N－Ammonia PET/CT心肌显像，计算并比较2种显像剂心肌显像的缺损分数、缺血/正常区域放射性计数比值和缺损体积。采用配对t检验和两样本t检验处理数据。结果8只巴马小型猪造模成功，4只死亡。造模后1、3和6个月，11C－MDA及13N－Ammonia心肌显像的缺损分数差异有统计学意义（13.4±3.3和7.4±1.0，18.8±4.4和4.8±1.0，10.5±4.2和4.4±0.9；t值：4.901、8.864和4.030，均P〈0.001）。造模后1和3个月，11C－MDA及13N－Ammonia心肌显像的缺血/正常区域放射性计数比值差异有统计学意义（0.47±0.14和0.59±0.10，0.43±0.13和0.61±0.09；t值：－2.166和－3.415，均P〈0.05）。造模后1、3和6个月，11C－MDA及13N－Ammonia心肌显像的缺损体积差异有统计学意义[（4.20±0.34）和（2.55±0.11） cm3，（10.66±0.71）和（2.46±0.12） cm3，（5.95±0.50）和（2.44±0.11） cm3；t值：12.925、32.149和19.440，均P〈0.001]。 结论心肌缺血再灌注恢复与心脏交感神经恢复有着不同的时间窗，前者要早于后者。ObjectiveTo evaluate 11C-MDA, a cardiac sympathetic nerve presynaptic molecular probe, in acute myocardial ischemia （AMI） and to compare with 13N-Ammonia myocardial perfusion imaging. MethodsTwelve Bama miniature pigs were used to establish AMI models. 11C-MDA and 13N-Ammonia PET/CT were performed before and after model establishment. The defect fraction, ratio of defect to normal region, defect volume of 11C-MDA and 13N-Ammonia PET/CT were calculated. Paired-t test and two-sample t test were used.ResultsEight models were established successfully and 4 pigs died. The defect fractions on 11C-MDA and 13N-Ammonia myocardial imaging were significantly different （13.4±3.3 vs 7.4±1.0, 18.8±4.4 vs 4.8±1.0, 10.5±4.2 vs 4.4±0.9; t values： 4.901, 8.864, 4.030, all P〈0.001） at the first, third and sixth month post-model establishment. The ratios of defect to normal region on 11C-MDA and 13N-Ammonia PET/CT myocardial images were significantly different （0.47±0.14 vs 0.59±0.10, 0.43±0.13 vs 0.61±0.09; t values： -2.166, -3.415, both P〈0.05） at the first and third month post-model establishment. The defect volumes on 11C-MDA and 13N-Ammonia PET/CT were significantly different （（4.20±0.34） vs （2.55±0.11） cm3, （10.66±0.71） vs （2.46±0.12） cm3, （5.95±0.50） vs （2.44±0.11） cm3;t values： 12.925, 32.149, 19.440, all P〈0.001） at the first, third and sixth month post-model establishment.ConclusionsMyocardial ischemia-reperfusion and cardiac sympathetic restoration might occur at different times. The recovery of myocardial ischemia-reperfusion is earlier than that of the cardiac sympathetic nerve.

关 键 词：心肌缺血 交感神经系统 正电子发射断层显像术 体层摄影术 X线计算机 脱氧肾上腺素 氨 猪 

分 类 号：R54[医药卫生—心血管疾病] R817.4[医药卫生—内科学]