128例颈项透明层厚度异常染色体正常胎儿妊娠结局分析  

Pregnancy Outcome of 128 Fetuses with Increased Nuchal Translucency but Normal Karyotype

作　　者：蒋瑜[1] 杨太珠[1] 罗红[1] 

机构地区：[1]四川大学华西第二医院超声科出生缺陷与相关妇儿疾病教育部重点实验室,成都市610041

出　　处：《中国超声医学杂志》2017年第5期447-449,共3页Chinese Journal of Ultrasound in Medicine

基　　金："十二五"国家科技支撑计划项目(No.2014BAI06B05)

摘　　要：目的探讨胎儿颈项透明层厚度异常(NT≥3.5mm)染色体正常的单胎妊娠结局。方法随机选取NT测值≥3.5mm,染色体正常的单胎作为研究对象。随访每一位研究对象中孕期Ⅲ级超声筛查结果及妊娠结局。记录新生儿妊娠结局:健康新生儿、结构异常新生儿、宫内死亡、终止妊娠。结构异常新生儿、宫内死亡及终止妊娠定为不良妊娠结局。将NT测值分为四组:3.5~4.4mm、4.5~5.4mm、5.5~6.4mm、≥6.5mm。比较每一组新生儿妊娠结局。结果 128例纳入研究对象中,101例为健康新生儿,10例为结构异常新生儿,4例宫内死亡,13例因胎儿畸形行人工终止妊娠。胎儿不良妊娠结局的发生率随着NT测值的增高而增高。结论 NT测值异常染色体正常胎儿不良妊娠结局的发生率随NT测值的增高而增高。Objective The aim of this study was to investigate the pregnancy outcome of fetuses with increased nuehal translucency （NT≥3.5 mm） but normal karyotype. Methods Fetuses with abnormal nuchal translucency （≥3.5 mm） and normal chromosome were studied. Results of ultrasonography and pregnancy outcome were followed. Record the pregnancy outcomes： live births, newborn with structural defects, termination of pregnancy（TOP）, intrauterine fetal death （IUFD）. newborns with structural defects, TOP and IUFD were defined as adverse pregnancy out-comes. Fetuses were divided into four groups according to NT： 3.5--4.4 mm, 4.5--5.4 ram, 5.5--6.4 mm, ≥6.5 mm. Compare whether there were significant differences in pregnancy outcome among the four groups. Results Of the 128 high NT pregnancies with normal karyotype, 101 （78.9G） resulted in live births, 10（7.8%） newborns with structural defects,4（3.1%） IUFD and 13 （10.2%） TOP. The risk of an adverse pregnancy outcome increased with increasing NT. Conclusions Adverse pregnancy outcome increased with increasing NT, even with normal karyotype, however, the prognosis is good if the second trimester ultrasound screening is normal.

关 键 词：颈项透明层 染色体 妊娠结局 超声检查 产前 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]