老年患者不同抗心律失常药物治疗的有效性与安全性分析  

Analysis of the efficacy and safety in the elderly patients with anti-arrhythmic treatment

作　　者：乔树洲[1] 刘丽华[1] 贾彬莉[1] 党涛[1] 白志东[1] 王煜[1] 任艳红[1] 张新宇[1] 

机构地区：[1]兰州军区兰州总医院干一科,兰州730050

出　　处：《中国临床保健杂志》2017年第3期271-273,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨抗心律失常药物胺碘酮、酒石酸美托洛尔治疗老年心律失常的有效性与安全性。方法选择60岁以上心律失常患者162例,按照治疗方法分为观察组81例和对照组81例,观察组口服酒石酸美托洛尔25毫克/次,每日2次,服用4周;对照组口服胺碘酮片40毫克/次,每日2次,服用4周。观察患者心率、症状体征,Hollter总心率和最慢心率,并对药物不良反应进行描述和评价。结果 162例患者中心律失常纠正158例,总有效率97.53%;其中观察组有效78例,有效率96.3%;对照组有效80例,有效率98.77%;两组有效率差异无统计学意义(P>0.05)。观察组不良反应14例,发生率17.28%;对照组不良反应发生率25例,发生率30.86%,两组不良反应发生率差异有统计学意义(P<0.05)。结论老年心律失常患者使用胺碘酮、酒石酸美托洛尔后,均发生总心率减慢,但酒石酸美脱洛尔不良反应总发生率小于胺碘酮,所以对于老年心律失常患者,酒石酸美托洛尔安全性优于胺碘酮。Objective To study the efficacy and safety of anti-arrhythmic drug amiodarone and metoprolol tar-trate in the treatment of senile arrhythmia. Methods 162 patients with arrhythmic and aged over 6 0 ,were randomly chosen. According to the treatment methods,the patients were divided into observation group with oral tartaric acid meto-prolol （25mgx2/day orally,4 weeks,81 cases） and control group with amiodarone tablets （40 mg x2/day orally,4 weeks, 81 cases）. The heart rate, symptoms and signs of patients were observed. Hollter total heart rate and slow heart rate,and adverse drug reactions were described and evaluated. Results Among 162 cases, 158 cases, of arrhythmia were corrected after treatment and the total efficiency was 97. 53%. In the observation group, the effectiveness was 96. 3% with 78 cases. In the control group,the effectiveness was 98. 77% with 80 cases. There were no statistically sig- nificanct difference between the two groups （P 〉 0. 05 ） . Adverse reactions occurred in 14 cases of the observationgroup,and the incidence rate was 17. 28% . Whereas,the adverse reactions occurred in 25 cases of the control group and the incidence rate was 30. 86%. There was a statistically significant difference in the two groups （ P 〈 0. 05 ） . Conclu-sion The adverse reaction with slowing total heart rate occurred in elderly patients with cardiac arrhythmia after the two antiarrhythmic drug therapy. The adverse reactions of metoprolol tartrate are less than those of amiodarone hydrochloride, and thus the safety of metoprolol tartrate is better than amiodarone for the elderly patients with arrhythmia.

关 键 词：胺碘酮 美托洛尔 药物毒性 老年人 

分 类 号：R541.7[医药卫生—心血管疾病]