五氯柳胺合成工艺改进  

Improved Synthesis of Oxyclozanide

作　　者：王学成 苏文杰 刘祥宜 朱建民 

机构地区：[1]江苏省兽用抗寄生虫药物工程技术研究中心,江苏常州213127

出　　处：《浙江化工》2017年第5期18-19,51,共3页Zhejiang Chemical Industry

基　　金："十二五"国家科技支撑计划项目--新型动物专用化学药物的创制及产业化关键技术研究(2015BAD11B01)

摘　　要：以2,4-二氯-6-硝基苯酚为原料,依次通过催化加氢还原,与3,5,6-三氯水杨酸酰氯缩合,并在甲醇/水中加入还原性脱色剂精制得到五氯柳胺。总收率由原来的54.8%提高至89.6%,纯度达99.9%(HPLC测得)。产物结构经~1H NMR、元素分析及MS进行了表征。Oxyclozanide was prepared from 2,6-dichloro- 4 -nitrophenol via catalytic hydrogenation, condensation with 3 , 5 , 6-trichlorosalicylryl chloride , and finally purification by reductive decoloring agent in methanol. The overall yield of oxiconazole nitrate was increased from 54.8% to 89.6 %, with a purity of 99.9%. The structures of the products were characterized by 1H NMR（MS spectra and organic elemental analysis.

关 键 词：五氯柳胺 催化加氢 2 4-二氯苯酚 3 5 6-三氯水杨酸 驱虫药 

分 类 号：S859.795[农业科学—临床兽医学]