四川大学华西医院丙型肝炎患者HCV病毒基因分型及临床特点的研究  

The investigation of genotypes of HCV and clinical characteristics in HCV patients in West China Hospital of Sichuan University

作　　者：王雪梅[1] 周娟[1] 叶远馨[1] 杨炼[1] 周易[1] 陆小军[1] 应斌武[1] 

机构地区：[1]四川大学华西医院实验医学科,成都610041

出　　处：《中国循证医学杂志》2017年第5期511-516,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金(编号:8167080772;81472026)

摘　　要：目的对四川大学华西医院的丙型肝炎患者HCV病毒基因分型特点进行分析,探讨HCV主要基因型与临床特征。方法纳入2011年3月~2016年9月就诊于四川大学华西医院HCV基因分型成功的4 520例HCV患者,对HCV基因型和主要基因型患者的肝功能、基线病毒载量进行分析,探讨HCV基因型在肝癌、肝硬化和HBV/HCV复合感染患者的分布情况。结果纳入患者的HCV基因型分为1、2、3、4、6五种基因型及23种亚型,基因型/亚型以1b、1*、3b、2a、3a、6a为主,分别占66.42%、8.01%、6.57%、4.54%、4.29%、3.41%。男性和女性中均以1b型为主,分别占29.89%和36.53%。HCV主要基因型/亚型在门(急)诊患者与住院患者中分布相似。HCV主要基因型/亚型在不同年龄段均以1b型占优。在男性中,6a亚型的ALT值最高;在女性中,3a亚型的ALT值最高。纳入的94例肝硬化患者中,1b型最高为42例;6例肝癌患者中,仅有1b和3b型检出。HCV和HBV双重感染患者共53例,基因型3a占比最高,共12例。结论四川大学华西医院就诊HCV患者HCV基因型/亚型具有独特的分布特点,以1b、1*、3b、2a、3a、6a为主。Objective To investigate HCV genotypes in HCV patients in West China Hospital of Sichuan University, and to analyze the major genotypes and clinical characteristics. Methods From March 2011 to September 2016, 4 520 HCV patients who were successfully genotyped HCV genotypes were enrolled in West China Hospital of Sichuan University. The genotypes distributions and the characteristics of laboratory characteristics of liver function, the viral loading were all analyzed. In addition, the genotypes in HCC patients, liver cirrhosis, HBC/HCV co-infection were also analyzed. Results HCV genotypes of HCV patients were divided into five genotypes of 1, 2, 3, 4, 6 and 23 subtypes, including predominant genotypes/subtypes 1b, 1^＊, 3b, 2a, 3a and 6a, accounting for 66.42%, 8.01%, 6.57%, 4.54%, 4.29%, and 3.41%, respectively. Subtype lb was the predominant subtype for both sex. In male patients, the levels of ALT were highest in 6a subtype, while in female, the levels of ALT were highest in 3a subtype. For the 94 liver cirrhosis patients, 42 patients were lb subtypes; as for the 6 HCC patients, lb and 3b subtypes were the only detected. Conclusion HCV genotypes/subtypes of HCV patients in West China Hospital of Sichuan University have unique characteristics of distribution, while the predominant genotype/subtypes are 1b, 1^＊, 3b, 2a, 3a, 6a.

关 键 词：四川大学华西医院 丙型肝炎病毒 基因分型 

分 类 号：R512.63[医药卫生—内科学]