肿瘤因子α-L-岩藻糖苷酶参考值的空间分布规律  

Spatial Variation of Reference Value of Tumor Biomarker:Alpha-L-Fucosidase

作　　者：李鹏[1,2] 葛淼[1] 王聪霞[3] 马维冬 杨绍芳[1] 林倩怡[1] 韦德智 

机构地区：[1]陕西师范大学旅游与环境学院健康地理研究所 [2]地理学国家级实验教学示范中心(陕西师范大学),陕西西安710119 [3]西安交通大学医学院第二附属医院心内科,陕西西安710004

出　　处：《中山大学学报（医学科学版）》2017年第3期459-467,共9页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(40971060);陕西师范大学研究生创新基金重点项目(2016CSZ005);中央高校基金资助项目(GK201504015)

摘　　要：【目的】研究中国健康成年人α-L-岩藻糖苷酶(AFU)空间分布趋势及其与地理因素之间的关系,为临床制定AFU科学标准提供地域性依据。【方法】收集2004-2015年全国66个市县级单位测定的6 564例健康人AFU参考值,其中男性3 701例(56.4%)女性2 863例(46.3%),运用信息含量法从22项地理因素中筛选出11项因素,并采用岭回归分析模拟出全国2322个市县级单位的参考值,然后运用地统计分析方法,分析AFU参考值在空间位置的分布特征。【结果】我国2 322个市县级单位健康成年人AFU参考值在空间上存在自相关特征,空间分布上呈现出东部高、西部低、北部高、南部低的空间分布趋势。【结论】AFU参考值在空间上存在变异性,因此在临床诊断中应该考虑地域性差异。[ Objective ] To refer a geographical distribution rule of alpha-L-fucosidase （AFU） reference values for the health adults in China via exploring its spatial distribution trend and its correlation with geographical factors. [ Methods ] A total of 6564 samples of AFU reference values from 66 administrative units in the years 2004-2015 were collected, male and female of which were 3701 cases （56.4%） and 2863 cases （46.3%）. A research concerning AFU reference values in whole country were calculated using methods of information content and ridge regression. [ Results ] AFU reference values for Chinese healthy adults were influenced by geographical factors and presented autocorrelation, and it showed eastern and northern areas were highery than western and southern areas. [ Conclusions ] AFU reference values have a spatial variation and the regional disparities should be considered in practice.

关 键 词：Α-L-岩藻糖苷酶 地理因素 岭回归 空间变化 

分 类 号：R188[医药卫生—流行病学]