在恒河猴基因组学框架下研究人类演化与调控  

Understanding human biology in the genomic context of rhesus macaque

作　　者：钟晓明[1] 申晴[1] 彭继光[1] 李玉梅[1] 李川昀[1] 

机构地区：[1]北京大学分子医学研究所,北京100871

出　　处：《生命科学》2017年第3期230-236,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31522032;31471240;31221002;31171269)

摘　　要：恒河猴作为人类近缘的模式生物,在基础与转化医学研究中具有独特优势,但其应用受到功能基因组学数据匮乏、基因结构混乱、研究平台缺乏等限制。近年来,深度测序技术的发展为突破这些技术瓶颈提供了机遇。现综述在深度测序技术支撑下,以恒河猴为背景开展的基因组学与分子演化研究,以期抛砖引玉,推动非人灵长类领域的研究进程。With human-comparable genome sequence and the advantages as model animal, rhesus macaque poses a unique model in molecular and translational study of human diseases. Despite these unique advantages, several unresolved issues have limited the current use of the model--inadequate functional genomics annotations, errorprone gene models, and lack of a platform for visualizing and assessing high-throughput data. With the development of the deep sequencing technology, some of these key issues have been addressed these years. Here we summarized the monkey genomics and molecular evolution studies we performed in the deep sequencing era.

关 键 词：恒河猴 深度测序 人类演化 猴基因组学 

分 类 号：Q343.1[生物学—遗传学] Q789