神经肌肉接头突触发育信号机制研究进展  

Progresses and perspectives of signaling mechanisms underlying neuromuscular synapses development

作　　者：杨海红[1] 吴海涛[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《生命科学》2017年第3期277-291,共15页Chinese Bulletin of Life Sciences

基　　金：国家重点基础研究发展计划("973"项目)(2014CB542203);国家自然科学基金项目(31371149;315-22029);北京市科学技术委员会"脑认知与脑医学"专项资助项目(Z161100000216154);北京市科技新星项目(Z131102000413033)

摘　　要：神经肌肉接头是目前研究较为深入的一种经典外周胆碱能化学突触。神经肌肉接头突触形成依赖于运动神经元与骨骼肌细胞之间的精细相互作用和复杂信号传递。此外,胶质细胞在神经肌肉接头突触发育和成熟过程中亦发挥重要功能。现将主要围绕近年来神经肌肉接头发育过程中若干重要信号通路以及相关神经肌肉系统疾病的主要研究进展进行综述。Neuromuscular junction （NMJ） is a classical peripheral cholinergic chemical synapse which has been extensively studied to date. The formation of NMJ synapses relies on the precise interaction as well as complicated signaling transduction between motoneurons and skeletal muscle fibers. Moreover, Schwann cells also play a critical role during NMJ synapses development and maturation. This review highlights recent advances in the study of NMJ development, focusing on several crucial signaling pathways, and related neuromuscular disorders as well.

关 键 词：神经肌肉接头 运动神经元 骨骼肌细胞 胶质细胞 

分 类 号：Q42[生物学—神经生物学] R338.13[生物学—生理学]