阿片药引起痛觉过敏的分子机制  

The molecular mechanisms of opioid-induced hyperalgesia

作　　者：孙樱桐 金华[1,2] 

机构地区：[1]昆明理工大学医学院,昆明650500 [2]昆明理工大学附属云南省第一人民医院,昆明650500

出　　处：《生命科学》2017年第4期364-370,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金地区项目(31360246);国家自然科学基金青年项目(81300973);云南省科技厅面上项目(2013FB100);云南省高校联合专项面上项目(2014FB100)

摘　　要：阿片类药物是临床上镇痛及手术麻醉的常用药物,具有催眠、镇痛、镇静、抑制不良应激反应等作用。然而,阿片类药物引起的恶心、呕吐、便秘、呼吸抑制等副作用极大地限制了其临床应用和推广。近年来,阿片类药物诱导的痛觉敏化现象引起了学者们的高度关注。痛觉敏化即使用阿片药物患者对疼痛刺激敏感性增加的现象,其机制可能与中枢神经可塑性改变有关,造成促伤害性感受通路敏化,剂量效应曲线右移。现将对阿片药诱导痛觉敏化的研究进展进行综述。Opioids are the most effective drugs used for moderating severe pain and are common anesthetic used for surgery, which produce sedative, hypnotic and analgesic effects. However, its clinical applications have been limited by its side effects such as nausea, vomiting and constipation. Besides, opioid-induced hyperalgesia has attracted greater attention recently. Opioid-induced hyperalgesia increases the thermal or mechanical sensitivity in patients receiving a prolonged treatment of opioids. The mechanism might involve the neural plastic changes in CNS, producing a rightward shift in the dose-effect curve. This article reviews the hypothesized mechanisms of opioid- induced hyperalgesia.

关 键 词：阿片类药物 痛觉敏化 分子机制 

分 类 号：R441.1[医药卫生—诊断学]