依帕司他联合甲钴胺对糖尿病周围神经病变患者生存质量的影响  

Effects of epalrestat combined with methylcobalamin on quality of life of patients with diabetic peripheral neuropathy

作　　者：刘香兰[1] 

机构地区：[1]衢州市人民医院内分泌科,浙江省衢州324000

出　　处：《中国基层医药》2017年第11期1623-1626,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨依帕司他联合甲钴胺对糖尿病周围神经病变患者生存质量的影响.方法 选取124例糖尿病周围神经病变患者,按照随机数字表法分为对照组和观察组,每组62例.两组在有效控制血糖的基础上加用药物以控制周围神经病变,其中对照组使用甲钴胺片,观察组使用依帕司他片联合甲钴胺片,两组均连续治疗60 d,观察两组主要生理指标变化、临床疗效及生存质量等.结果 观察组总有效率为95.2%,高于对照组的80.6%,差异有统计学意义（x2=3.072,P＜0.05）;空腹血糖（FPG）、餐后2 h血糖（2 h PPG）、糖化血红蛋白（HbA1c）均有所改善,与治疗前比较,差异均有统计学意义（均P＜0.05）,但观察组改善程度明显优于对照组,差异有统计学意义（P＜0.05）;观察组生活质量评估指标体疼痛（BP）、社会功能（SF）、生理机能（RP）和精神健康（MH）与对照组比较,差异均有统计学意义（t=16.964、44.583、30.204、44.114,均P＜0.05）.结论 采用依帕司他联合甲钴胺对糖尿病周围神经病变患者进行治疗,可显著改善血糖水平,缓解临床症状,提高患者的生活质量,具有较大的临床借鉴意义.Objective To evaluate the effect of epalrestat combined with methylcobalamin on quality of life of patients with diabetic peripheral neuropathy.Methods 124 patients with diabetic peripheral neuropathy were randomly divided into the control group and the observation group according to the random number table, each group had 62 cases.The two groups were treated on the basis of the effective control of blood glucose and medication to control peripheral neuropathy, the control group used mecobalamin, the observation group used epalrestat combined with methylcobalamin, the two groups were treated continuously for 60 days.The effects of two main physiological changes, clinical efficacy and quality of life were observed.Results The total effective rate of the observation group was 95.2%,which was higher than 80.6% of the control group, the difference was statistically significant（x2=3.072,P〈0.05）.The fasting plasma glucose（FPG）,postprandial 2 h plasma glucose（2 h PPG）, glycosylated hemoglobin（HbA1c） were improved compared with before treatment, the differences were statistically significant（all P〈0.05）,which of the observation group improved significantly better than the control group, the differences were statistically significant（all P〈0.05）.The evaluation indicators of body pain（BP）,social function（SF）, role physiological（RP） and mental health（MH） had statistically significant differences compared with the control group （t=16.964,44.583,30.204,44.114,all P〈0.05）.Conclusion Using epalrestat combined with methylcobalamin tablets in the treatment of patients with diabetic peripheral neuropathy can significantly improve blood glucose levels, clinical symptoms, the quality of life of patients and it has great clinical significance.

关 键 词：糖尿病 周围神经系统疾病 依帕司他 甲钴胺 

分 类 号：R587.2[医药卫生—内分泌]