高密市2014年人群乙肝血清学调查结果分析  

Investrigation and analysis of hepatitis B serology of the crowd in Gaomi in 2014

作　　者：邱德山[1] 徐东[1] 王怡[1] 

机构地区：[1]潍坊市疾病预防控制中心,261061

出　　处：《中国医院统计》2017年第2期88-91,共4页Chinese Journal of Hospital Statistics

摘　　要：目的了解高密市乙型病毒性肝炎(乙肝)流行现状,为完善乙肝疫苗策略提供科学依据。方法 2014年10月,采取分层多阶段随机抽样方法,抽取高密市1~、5~、15~和30~59岁常住人口为调查对象,开展血清流行病学调查。用酶联免疫吸附试验(ELISA)检测HBsAg、Anti-HBs、Anti-HBc、HBeAg和Anti-Hbe。结果共调查497人,其HBV流行率、HBsAg阳性率、Anti-HBs阳性率和Anti-HBc阳性率分别为12.55%、1.42%、52.02%和12.55%。HBV流行率、HBsAg阳性率、Anti-HBs阳性率、Anti-HBc阳性率男女之间差异均无统计学意义(X^2=0.03,0.41,0.25,0.01,P>0.05)。各年龄组之间:HBV流行率,1~、5~、15~、30~59岁组分别为2.14%、0.99%、17.53%、26.28%,差异有统计学意义(X^2=55.10,P<0.01),5~岁组最低,30~59岁组最高,随年龄增长而呈现升高的趋势。HBsAg阳性率:1~、5~岁组未检出,15~、30~59岁组分别为2.06%、3.21%,差异无统计学意义(X^2=7.32,P>0.05)。Anti-HBs阳性率:1~、5~、15~、30~59岁组分别为67.86%、55.45%、54.64%、33.97%。差异有统计学意义(X^2=35.16,P<0.01),随年龄增长而呈现下降的趋势。Anti-HBc阳性率:1~、5~、15~、30~59岁组分别为2.14%、0.99%、17.53%、26.28%,差异有统计学意义(X^2=55.10,P<0.01),5~岁组最低,随年龄增长而呈现升高的趋势。结论高密市目前仍为乙肝中度流行区,青少年和成人中HBV流行强度高于儿童,高密市实施以"新生儿HePB接种"为主的乙肝控制策略取得了显著成效。Objective To understand the epidemic status of hepatitis B （HBV） in Gaomi, and provide scientific basis for improving the strategy of hepatitis B vaccine. Methods In October 2014, a stratified nmhi-stage random sampling method was adopted to investigate the prevalence of serum epidemiology in Gaomi among 1 - , 5＋ , 15 - and 30 -59 year-old group res- ident population. Enzyme linked immunosorbent assay （ELISA） was used to detect HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-Hbe. Results A total of 497 people were investigated, the prevalence rate of HBV, HBsAg positive rate, Anti-HBs posi- tive rate and Anti-HBc positive rate were 12.55% , 1,42% , 52.02% and 12.55% respectively. The differences of HBV preva- lence rate, HBsAg positive rate, positive rate of Anti-HBs, and positive rate Anti-HBc between men and women had no statistical significance （χ^2=0. 03 ,0. 41 ,0. 25 and 0.01, P〉0.05 ）. Among the age groups ： the prevalence rate of HBV among 1 - , 5-, 15 - and 30 -59 group were 2.14% , 0.99% , 17.53% and 26.28% respectively. The difference was statistically significant （χ^2= 55. 10, P〈0.01 ）. The rate for the 5 - year-old group was the lowest, the rate for the 30 -59 year-old group was the high- est, showing a increasing trend with the age growth. HBsAg positive rate for 1 to 5 - year-old group wasn＇t detected out, those for 15 - , 30 - 59 age groups were 2.06% and 3.21% , without statistically significant differences （Xz = 7.32, P〉0. 05 ）. The posi- tive rates of Anti-HBs： 1-, 5-, 15- and 30 - 59 year-old groups were 67.86%, 55.45% , 54.64% , 33.97% respectively. The difference was statistically significant （X2 = 35.16, P〈0.01 ） , showing a decreasing trend with the age growth. The positive rates of Anti-HBc for 1 - , 5 - , 15 - and 30 -59 were 2.14% , 0.99% , 17.53% , 26.28% respectively. The difference was statistically significant （χ^2= = 55.10, P〈0.01 ） , with the 5 - year-old group the lowest, and the rate increased with age. Conclu- sion Gaomi is still the mo

关 键 词：人群 乙型病毒性肝炎 血清流行病学 

分 类 号：R512.620.1[医药卫生—内科学]