动脉粥样硬化程度与患者血清中趋化素和纤连蛋白EDA水平的相关性  

Correlation between degree of atherosclerosis and serum levels of chemokines and EDA-fibronectin

作　　者：吴佳[1] 任雨笙[2] 张治宇[1] 张璐定[1] 

机构地区：[1]第二军医大学长征医院贵宾诊疗科,上海200003 [2]第二军医大学长征医院心血管内科,上海200003

出　　处：《心脏杂志》2017年第3期293-296,共4页Chinese Heart Journal

基　　金：上海长征医院青年启动基金项目资助(2016CZQN11)

摘　　要：目的分析动脉粥样硬化(AS)程度与患者血清中趋化素(chemerin)和纤连蛋白EDA片段(EDA-FN)水平的相关性。方法 102例颈AS患者根据病症的严重程度分为轻度AS组(轻度硬化组,颈内动脉收缩期峰值流速在125~230 cm/s,动脉内径缩小<30%)和重度AS组(重度硬化组,颈内动脉收缩期峰值流速>230 cm/s,动脉内径缩小>70%),采用ELISA方法测定患者血清中趋化素和EDA-FN的含量,并收集患者的相关临床资料。结果重度硬化组患者血清趋化素含量和EDA-FN水平显著高于轻度硬化组(P<0.05,或P<0.01),AS程度与血清趋化素含量呈正相关(r=0.212,P<0.01),与EDA-FN水平呈正相关(r=0.283,P<0.01)。结论 AS程度与血清中趋化素和EDA-FN水平有相关性。AIM To explore the clinical significance of changes of chemerin and EDA-fibronectin （EDA-FN） in serum of patients with atherosclerosis （AS）. METHODS One hundred and two AS patients were divided into severe AS group （sAS group） and mild AS group （mAS group） according to the degree of AS. Fifty healthy subjects were included as normal control group （ normal group）. ELISA was used to measure the contents of chemerin and EDA-FN in serum of the three groups. RESULTS Contents of ehemerin and EDA-FN in serum of the sAS and mAS groups were significantly higher than those in the normal control group （ P 〈 0. 05 ）. Contents of chemerin and EDA-FN in serum of the sAS group were significantly higher than those in the mAS group （ P 〈 0. 05 ）. CONCLUSION Levels of chemerin and EDA-FN in serum of AS patients increase significantly compared with those in healthy subjects and the levels are positively correlated with the degree of AS. Detecting the contents of chemerin and EDA-FN in serum is helpful in clinical diagnosis and prognosis of AS patients.

关 键 词：动脉粥样硬化 趋化素 纤连蛋白EDA片段 

分 类 号：R543.5[医药卫生—心血管疾病]