重度慢性心力衰竭患者血尿酸水平与预后的关系  

Relationship between uric acid and prognosis in patients with severe congestive heart failure

作　　者：陆金帅[1] 李楠[1] 薛克栋[1] 

机构地区：[1]新疆维吾尔自治区人民医院重症医学一科,新疆乌鲁木齐830001

出　　处：《心脏杂志》2017年第3期304-306,共3页Chinese Heart Journal

摘　　要：目的分析血清尿酸(SUA)水平与重度慢性收缩性心力衰竭(CHF)患者预后的关系。方法收集2014年4月~2015年1月于我院住院纽约心脏病协会(NYHA)心功能Ⅳ级CHF患者189例,对其随访6个月,终点事件为全因死亡。分析入院SUA水平与CHF住院患者6个月内全因死亡的关系。结果按随访结果将患者分为死亡组和存活组。死亡组入院SUA水平明显高于存活组[(514±30)μmol/L vs.(432±32)μmol/L,P<0.01]。Pearson分析显示N末端脑钠尿肽前体(NT-proBNP)与SUA具有正相关性(r=0.345,P<0.05)。多因素Logistic回归分析显示,SUA水平(OR=1.213,95%CI:1.081-3.621,P<0.05),NT-proBNP(OR=1.456,95%CI:1.113-5.432,P<0.01),糖尿病(OR=2.105,95%CI:1.221-4.553,P<0.05)是CHF患者6个月全因死亡事件发生的独立危险因素。结论血清SUA水平与重度CHF预后有相关性。AIM To investigate the association between serum uric acid （SUA） and prognosis in patients with severe congestive heart failure （CHF）. METHODS One hundred and eighty-nine consecutive patients with severe CHF hospitalized from April 2014 to January 2015 were included and the incidence of all-cause mortality during 6 months was observed. Statistical analyses were performed using SPSS 17.0. RESULTS Compared with the control group, uric acid level was significantly increased in all-cause mortality group [ （514 ± 30 ） vs. （432 ± 32 ） μmol/L, P 〈 0.01 ]. Pearson related analysis indicated that the uric acid level was positively related to NT-proBNP （ r = 0. 345, P 〈 0. 05 ）. Multiple logistic regression analysis found that uric acid levels （ OR = 1. 213, 95% CI： 1. 081 - 3. 621, P 〈 0.05）, NT-proBNP （OR=1.456, 95%CI： 1.113-5.432, P〈0.01） and diabetes （OR=2.105, 95% CI： 1. 221 -4. 553, P 〈 0. 05） were the independent risk factors for all-cause mortality within 6 months in severe CHF patients. CONCLUSION SUA level is associated with the prognosis in patients with severe CHF.

关 键 词：血尿酸 心力衰竭 慢性 全因死亡 

分 类 号：R541.61[医药卫生—心血管疾病]