七氟烷与丙泊酚麻醉对老年肺癌患者术后认知功能影响的比较研究  

Comparative Study on Influence of Anesthesia with Sevoflurane or Propofol on Postoperative Cognitive Function in elder Patients with Lung Cancer

作　　者：杨红伟 田子荣 张红波 

机构地区：[1]山西省长治市首钢长钢医院

出　　处：《世界最新医学信息文摘》2017年第1期12-13,共2页World Latest Medicine Information Electronic Version

摘　　要：目的比较七氟烷与丙泊酚麻醉对老年肺癌患者术后认知功能影响的差异。方法对我院120例65岁以上的肺癌患者进行肺癌根治手术,将所有患者随机分为七氟烷组(n=60)和丙泊酚组(n=60),分别于手术前及术后对患者进行简易智能精神状态评分(MMSE),并于麻醉前、术后取血测定血清S100β蛋白。结果术前2组患者的MMSE评分、手术时间、麻醉时间及S100β蛋白水平均无明显差异(P>0.05);术后2组患者的MMSE评分均显著下降(P<0.05);术后6h、1d及3d两组患者的MMSE评分相比,七氟烷组均显著高于丙泊酚组,差异有统计学意义(P<0.05)。术后10min两组患者的S100β蛋白水平均显著升高,与术前10min相比差异有统计学意义(P<0.05),但2组间比较差异无统计学意义(P>0.05);术后1 d丙泊酚组患者的S100β蛋白水平明显高于七氟烷组,差异有统计学意义(P<0.05)。结论七氟烷和丙泊酚对老年肺癌患者全身麻醉术后认知功能均有影响,但七氟烷术后认知功能障碍的发生率低于丙泊酚,且恢复较快。Objective To compare the sevoflurane and propofol anesthesia on postoperative cognitive function in elderly patients with lung cancer effect difference. Methods A total of 120 patients older than 65 lung cancer patients with lung cancer radical surgery, all patients were randomly divided into sevoflurane group （n=60） and propofol group （n=60）, respectively in the preoperative and postoperative mental state for patients with simple intelligence score （MMSE）, and prior to anesthesia and postoperative blood serum according to beta protein. Results The MMSE score of preoperative 2 groups of patients, operation time, the time of anesthesia, and according to beta protein levels had no obvious difference （P〉0.05）; Postoperative patients of two groups of MMSE score were significantly decreased （P〈0.05）; After 6 h, 1 d and 3 d compared two groups of patients with MMSE score, sevoflurane group were significantly higher than that of propofol group, the difference was statistically significant （P〈0.05）. 10 min after two groups of patients according to beta protein levels were significantly increased, compared with the preoperative 10 min difference was statistically significant （P〈0.05）, but the difference is compared between two groups had no statistical significance （P〉0.05）; Conclusion Sevoflurane and propofol on cognitive function in elderly patients with lung cancer after general anaesthesia all have influence, but the incidence of postoperative cognitive dysfunction sevoflurane is lower than the propofol, and recover quickly.

关 键 词：七氟烷 丙泊酚 老年 肺癌 术后认知功能 

分 类 号：R614[医药卫生—麻醉学]