蟾皮提取物固体脂质纳米粒的制备工艺研究  

Study on the preparation technology of solid lipid nanoparticles in toad skin extract

作　　者：严子平[1] 张磊[2] 张莉[3] 王正[1] 

机构地区：[1]武警天津总队医院,天津300161 [2]武警后勤学院附属医院,天津300162 [3]武警后勤学院药剂教研室,天津300309

出　　处：《武警后勤学院学报（医学版）》2017年第1期37-41,共5页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】优选蟾皮提取物固体脂质纳米粒的制备工艺。【方法】采用探头超声法制备蟾皮提取物固体脂质纳米粒,以单因素考察和均匀设计筛选处方及工艺,并考察其包封率和载药量。【结果】最佳工艺:ATO 100 mg、大豆卵磷脂300 mg、药物300mg加入到5%P188 42 ml,0.5%TWeen-80 8 ml乳化150 min。【结论】该工艺适合蟾皮提取物固体脂质纳米粒的制备。[Objective] To optimize the technique for preparing solid lipid manoparticles （SLN） in toad skin extract. [Methods] [Methods] The SLN in toad skin were prepared via ultrasonic probe. The formula and technology were optimized by single factor design and uniform design. Encapsulation efficiency and loading capacity were determined. [ Results ] [Results] The optimized technology was that ATO 100 mg, soy lecithin, 300 mg and drug 300 mg were added to 5% P188 42 ml and 0.5% Tween-80 8 ml, and emulsified for 150 min. [Conclusion]The technology for preparing SLN in toad skin extract SLN is feasible.

关 键 词：蟾皮 固体脂质纳米粒 均匀设计 

分 类 号：R96[医药卫生—药理学]