纤毛、纤毛发生与Wnt/PCP信号通路  

Cilium,ciliogenesis and Wnt/PCP signaling pathway

作　　者：刘月华[1] 生燕 欧刚卫[1] 生欣[1] 

机构地区：[1]遵义医学院基础医学院生物化学教研室,遵义563000 [2]遵义医学院基础医学院形态学实验室,遵义563000

出　　处：《生命的化学》2017年第2期159-164,共6页Chemistry of Life

基　　金：国家自然科学基金项目(31360278);贵州省科技厅联合基金项目(黔科合J字LKZ[2013]28号)

摘　　要：纤毛是以微管为核心组分、突出于细胞表面且高度保守的细胞器,具有运动、摄食、感知并传递外界信号等功能。纤毛发生是纤毛在细胞膜表面定位并装配的过程。多年来,对纤毛发生过程及其调控机制的探索始终是亚细胞结构与功能研究的热点之一。Wnt/PCP信号通路是参与胚胎及器官发育的主要信号转导途径之一。近年来大量研究显示,Wnt/PCP信号通路和纤毛发生密切相关。纤毛结构与功能的异常可造成Wnt/PCP信号通路异常,导致纤毛相关疾病的发生;同时,Wnt/PCP信号通路又决定着纤毛的形态和极性。因此,深入研究纤毛与Wnt/PCP信号通路的关系将有助于从细胞与分子生物学水平揭示纤毛发生的调控机制。Cilium is a highly conserved and core microtubule-based organelle that projects from the sur- face of cells. Cilium plays the roles in moving, feeding, apperceiving and transmitting the external signals. Ciliogenesis is the process that cilium is located and assembled on the surface of cell membrane. Over years, investigating the process of ciliogenesis and its regulation mechanism has always been the focus of subcellu- lar structure and function research. Wnt/PCP signaling pathway is one of major signal transduction pathways involved in the development of embryo and organ. Recently, a large number of studies have shown that Wnt/ PCP signaling pathway is closely related to ciliogenesis. Dysfunction of cilium can deregulate Wnt/PCP sig- naling, resulting in ciliopathies. While Wnt/PCP signaling pathway in turn can determine the morphology and polarity of cilium. Therefore, the depth research on the correlation of cilium and Wnt/PCP signaling pathway will be helpful to reveal the regulation mechanism of ciliogenesis on the levels of cell and molecular biology.

关 键 词：纤毛 Wnt/PCP信号通路 纤毛相关疾病 

分 类 号：Q23[生物学—细胞生物学]