Wnt信号通路调控脂肪发育与代谢的研究进展  

Wnt signaling regulates adipose tissue formation and metabolism

作　　者：曹怡玮 郭熙志[1] 

机构地区：[1]上海交通大学Bio-X研究院,遗传发育与精神疾病教育部重点实验室,上海200240

出　　处：《中国科学：生命科学》2017年第4期355-362,共8页Scientia Sinica(Vitae)

摘　　要：肥胖是形成Ⅱ型糖尿病和心血管疾病的重要风险因子.Wnt信号通路是调控多个细胞发育与分化的重要信号因子.本研究介绍了脂肪组织结构、脂肪细胞分化的调控因子、经典和非经典Wnt信号通路.从肥胖与糖尿病的临床观察、脂肪分化与发育、线粒体代谢与炎症反应的角度,阐述了经典和非经典Wnt信号通路对脂肪发育和代谢的影响.Obesity is one of the main risk factors for type II diabetes and cardiovascular diseases, while Wnt signaling is one of the important signaling pathways implicated in multiple cellular differentiation and developmental processes. Here, we first describe adipose tissue formation, regulators for adipogenic differentiation, and the canonical and non-canonical Wnt signaling pathways. We then review the impact of Wnt signaling on adipose tissue formation as well as mitochondrial metabolism and inflammation, which are involved in obesity and diabetes development.

关 键 词：WNT信号通路 脂肪细胞分化 Ⅱ型糖尿病 

分 类 号：R58[医药卫生—内分泌]