胎儿静脉导管的多普勒血流频谱在孕早期胎儿先天性心脏病筛查中的临床应用研究  

Clinical application of Doppler flow spectroscopy of fetal venous catheter in screening of fetal congenital heart disease in early pregnancy

作　　者：陈基强 林明 王红华 

机构地区：[1]东莞康华医院超声科,广东523080

出　　处：《齐齐哈尔医学院学报》2017年第6期653-654,共2页Journal of Qiqihar Medical University

基　　金：东莞市科技计划医疗卫生类科研一般项目(201510515000465)

摘　　要：目的分析胎儿静脉导管的多普勒血流频谱在孕早期胎儿先天性心脏病筛查中的临床应用。方法选择在我院接受产前检查的200名孕早期(孕11~14周)单胎孕妇为研究对象,所有患者均接受彩色多普勒超声检测,获取胎儿静脉导管的多普勒血流频谱,并根据其频谱是否异常将研究对象分为异常组(研究组)和正常组(对照组),比较两组胎儿先天性心脏病发生率,并于孕18~24周对两组孕妇进行超声心动检查。结果 200名胎儿中,共19例胎儿静脉导管的多普勒血流频谱存在异常,占9.5%,并纳入研究组。研究组胎儿的先天性心脏病发生率57.9%(11/19),显著高于对照组胎儿的先天性心脏病发生率5.0%(9/181),差异有统计学意义(χ~2=53.510,P<0.001)。研究组胎儿的整个心动周期均为前向血流,心房收缩期无反转血流;对照组胎儿主要表现为心房收缩期出现反转血流和波缺损。结论胎儿静脉导管的多普勒血流频谱可作为我国临床筛查孕早期胎儿先天性心脏病的重要辅助指标。Objective To analyze the clinical application of Doppler flow spectroscopy of fetal venous catheter in screening of fetal congenital heart disease in early pregnancy. Methods 200 case of pregnant women（ 11-14 weeks） with singleton fetus who received prenatal examination in our hospital were enrolled in this study.Color Doppler ultrasonography was performed on 200 cases of pregnant women. Doppler blood was obtained from fetal venous catheters According to the Doppler flow spectrum,200 case of pregnant women were divided into study group（ abnormal） and control group（ normal）. Echocardiography was performed on 18 - 24 weeks＇ pregnant women. Results In the study group,11 cases were diagnosed as congenital heart disease by echocardiography,the proportion was 57.9%,which was higher than that of the control group（ P〈0.05）. The whole cardiac cycle of normal fetus was the blood flow,atrial systolic without reversal of blood flow; congenital heart disease fetal Doppler flow spectrum abnormalities mainly in atrial systolic reversal of blood flow and atrial systolic wave defect.Conclusions Doppler blood flow spectrum of fetal venous catheters can be used as an important auxiliary index for clinical screening of fetal congenital heart disease in early pregnancy.

关 键 词：心脏病 先天性 孕早期 静脉导管 多普勒血流频谱 

分 类 号：R714.5[医药卫生—妇产科学]