基于壳聚糖构建的递送抗生素系统  

Chitosan-Based Shuttles Transporting Antibiotics

作　　者：刘莉[1] 徐婷婷[1] 

机构地区：[1]湖北医药学院附属随州医院药学部,湖北随州441300

出　　处：《药物生物技术》2017年第2期167-170,共4页Pharmaceutical Biotechnology

摘　　要：抗生素目前依然是治疗感染性疾病的唯一选择,它们可以单独使用,或者跟其他药物联合使用。但是,抗生素理化性质的局限性、毒副作用和日益严重的细菌耐药性不容忽视。近年来,基于生物材料构建的给药系统在纳米技术条件下迅猛发展,纳米尺度的制剂往往具有靶向性、长效性和可控性,有力改善了药物的疗效,降低了用药剂量和毒副作用。壳聚糖有极好的生物相容性、生物可降解性和抗菌活性,是极具应用价值的高分子材料和添加剂。通过参阅近3年来的文献,作者概述了壳聚糖在纳米给药系统中作为抗生素载体的应用,特别是能显著改善抗生素对耐药菌、生物膜和胞内细菌的抑制活力,展示该生物大分子的临床应用前景。Although antibiotics are still the sole choice for treating infections either in unique or in combined therapeutic schemesand a series of limitations related to the physico-chemical properties of the drug, the adverse response and increasing resistance todrugs resulting from antibiotics should be overcome. The great advances have been recently on the nanotechnological field regardingthe development of biomaterial-base efficient drug delivery systems. Nanostructurated vehicles for the targeted, prolonged andcontrolled release of antibiotics are increasing their therapeutic efficiency, while they are reducing the required active doses andconsequently the adverse effects on the host. Chitosan has been applied extensively as a biopolymer and additive for nanomaterialsowing to its excellent biocompatibility, biodegradability, and good antimicrobial activity. By consulting documents in recent threeyears, author highlighted in the short review the main types of chitosan served as carriers enhancing the efficiency of active antibioticsagainst infections difficult to treat, especially such as those caused by resistant strains, biofilms and intracellular bacteria, showinggreat promises with respect to developing clinical formulations.

关 键 词：壳聚糖 抗生素 纳米 结构修饰 载体 生物材料 

分 类 号：Q7[生物学—分子生物学]