注射用磷酸特地唑胺体内抗菌作用研究  

In vivo activity of tedizolid phosphate injection

作　　者：谭娇梅 乔红群[1] 丁亚军[2] 王虎斌[2] 杨建树[1] 

机构地区：[1]南京工业大学,南京210009 [2]江苏省药物研究所,南京21009

出　　处：《中国抗生素杂志》2017年第5期425-428,共4页Chinese Journal of Antibiotics

摘　　要：目的研究注射用磷酸特地唑胺对金黄色葡萄球菌、粪肠球菌、化脓性链球菌的体内抗菌作用。方法选取SPF级ICR小鼠,选用标准菌株金黄色葡萄球菌(ATCC29213)及金黄色葡萄球菌(n=22)、粪肠球菌(n=18)和化脓性链球菌(n=63)3株临床分离的致病菌,以0.5m L最低致死菌量腹腔注射细菌感染小鼠,建立小鼠败血症模型;于造模1h后,分别静脉注射给予不同浓度的注射用磷酸特地唑胺和利奈唑胺注射液药液,记录给药后1~7d小鼠存活数,用BLISS法计算ED50、ED95及P值。结果注射用磷酸特地唑胺对金黄色葡萄球菌标准菌株及3株临床分离的致病菌的ED50值在1.57~3.52mg/kg,ED95值在3.86~8.21mg/kg,均明显优于对照药利奈唑胺注射液(P<0.01)。结论注射用磷酸特地唑胺对所测标准菌株及临床分离的致病菌有较好的体内抗菌作用,其作用明显优于同类药利奈唑胺注射液。Objective To evaluate the in vivo activity of tedizolid phosphate injection in the treatment of mouse septicemia caused by Staphylococcus aureus, Enterococcus faecalis and Streptococcus pyogenes. Methods The SPF ICR mice and a standard strain of Staphylococcus aureus （ATCC29213） and other three clinical isolated pathogenic bacteria of Staphylococcus aureus （n=22）, Enterococcus faeealis （n=18） and Streptococcus pyogenes （n=63） were selected. The mouse septicemia model was established by an intraperitoneal injection of the suspensions （minimal lethal dose） of bacteria 0.5mL. Tedizolid phosphate and linezolid were injected to the mice lh after the bacteria injection. The survivals of the infected mice were monitored for seven days, and the ED50, ED95 and P values were calculated by the BLISS method. Results The EDs0and ED95 of tedizolid phosphate injection against the standard strain of Staphylococcus aureus （ATCC29213） and other three clinical isolated pathogenic bacteria of Staphylococcus aureus （n=22）, Enterococcusfaecalis（n=1 8） and Streptococcus pyogenes （n=63） were 1.57-3.52mg/kg and 3.86-8.21mg/kg, which were better than those of the control drug linezolid injection. Conclusion Against the standard strains and clinical isolates pathogens, tedizolid phosphate injection shows a better in vivo antibacterial activity than the drug line zolid injection.

关 键 词：注射用磷酸特地唑胺 败血症 体内抗菌作用 

分 类 号：R978.1[医药卫生—药品]