产前检测羊水卵磷脂/鞘磷脂比值预测新生儿呼吸窘迫综合征的价值  

Predictive value of prenatal amniotic fluid lecithin/sphingomyelin ratio for neonatal respiratory distress syndrome

作　　者：涂新枝[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院产科,广东深圳518028

出　　处：《中国妇幼保健》2017年第10期2122-2124,共3页Maternal and Child Health Care of China

摘　　要：目的探讨高效液相色谱法(HPLC)检测羊水卵磷脂/鞘磷脂(L/S)比值产前预测新生儿呼吸窘迫综合征(RDS)的价值。方法对55例羊水标本采用HPLC检测羊水L/S比值,受试者工作特征曲线(ROC)分析HPLC检测羊水L/S比值产前预测RDS的效率。结果 RDS组羊水L/S比值明显低于非RDS组,差异有统计学意义[(4.14±1.80)vs.(19.56±15.76)],P<0.05)。羊水L/S比值以5.778为切割值,L/S比值产前预测RDS的ROC曲线下面积为0.969,灵敏度和特异度分别为92.3%和95.2%。结论 HPLC检测羊水L/S比值产前预测RDS是一种非常有潜力可用于临床的理想方法。Objective To explore the predictive value of prenatal amniotie fluid lecithin/sphingomyelin （L/S） ratio for neonatal respiratory distress syndrome （RDS） using high performance liquid chromatography （HPLC） . Methods HPLC was used to detect amniotic fluid L/S ratio in 55 pregnant women. Receiver operating characteristic curve （ROC） was used to analyze the predictive efficiency of amniotic fluid L/S ratio for RDS using HPLC. Results Amniotic fluid L/S ratio in RDS group was （4. 14 ±1.80） , which was statistically significantly lower than that in non-RDS group （ 19.56 ±15.76） （ P〈 0. 05） . When taking 5. 778 as cut-off value of amniotic fluid L/S ratio, the area under ROC curve was 0. 969, the sensitivity and specificity were 92. 3% and 95.2% , respectively. Conclusion Amniotic fluid L/S ratio using HPLC may be a promising and clinical useful method to predict RDS prenatally.

关 键 词：高效液相色谱法 卵磷脂/鞘磷脂 预测 新生儿呼吸窘迫综合征 

分 类 号：R714[医药卫生—妇产科学]