宫颈环形电切术与冷刀锥切术治疗宫颈上皮内瘤变的Meta分析  

Meta analysis on loop electrosurgical excision procedure and cold knife conization in treatment of cervical intraepithelial neoplasia

作　　者：李莉[1] 赵霞[1] 张绪婷 贺丹[1] 王苹[1] 李淑萍[1] 

机构地区：[1]石河子大学医学院第一附属医院妇产科,新疆石河子832000

出　　处：《中国妇幼保健》2017年第10期2258-2263,共6页Maternal and Child Health Care of China

基　　金：财政部科技惠民计划项目(2013GS650104)

摘　　要：目的探讨宫颈环形电切术(loop electrosurgical excision procedure,LEEP)与冷刀锥切术(cold knife conization,CKC)治疗宫颈上皮内瘤变(CIN)效果。方法计算机检索Pub Med、EMBASE、Cochrane Library、CBM、CNKI、万方数据库等方式收集相关文献。通过Revman 5.3软件对术中出血量、手术时间、切口愈合时间、术后出血等方面进行Meta分析。结果共纳入9篇文献,1 107例患者。两种术式在手术时间、术中出血、切口愈合、宫颈粘连及术后出血方面比较,差异有统计学意义(P<0.05)。在病理符合、CIN级别降低、切缘阳性、转移浸润方面无统计学差异(P>0.05)。结论 LEEP以其出血少,恢复快,价格低廉,操作简便等明显优势值得在临床推广应用。Objective To explore the effects of loop electrosurgical excision procedure （LEEP） and cold knife conization （CKC） in treatment of cervical intraepithelial neoplasia （CIN） . Methods The related literatures were collected by searching PubMed, EMBASE, Cochrane Library, CBM, CNKI, Wanfang database by a computer. Revman 5.3 software was used to analyze the amount of intraoperative blood loss, operation time, incision healing time, and postoperative hemorrhage by Meta analysis. Results Nine articles （1 107 patients） were included into this study. There were statistically significant differences in operation time, the amount of intraoperative blood loss, incision healing time, cervical adhesion, and postoperative hemorrhage between LEEP and CKC （ P〈0. 05） . There was no statistically significant difference in coincidence rate of pathological examination, decrease of CIN grade, positive incisal margin, invasion and metastasis between LEEP and CKC （P〉0.05） . Conclusion LEEP has the advantages of less bleeding, faster recovery, cheap price, and simple operation, which is worthy of clinical promotion and application.

关 键 词：宫颈环形电切术 宫颈上皮内瘤变 冷刀锥切 

分 类 号：R713[医药卫生—妇产科学]