天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的临床观察  

Clinical Observation of Tianqi Jiangtang Capsules Combined with Metformin in the Treatment of Elderly Patients with Type 2 Diabetes Mellitus Complicated with Cerebral Microvascular Lesions

作　　者：柴红[1] 路一芳[1] 肖红珍[1] 李颖 崔坤 张援月 

机构地区：[1]唐山市工人医院内分泌科,河北唐山063000 [2]唐山市工人医院危重症内科,河北唐山063000 [3]唐山市工人医院呼吸危重症内科,河北唐山063000

出　　处：《中国药房》2017年第15期2053-2057,共5页China Pharmacy

摘　　要：目的:观察天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的疗效和安全性。方法:96例老年2型糖尿病伴脑微血管病变患者随机分为对照组(48例)和观察组(48例)。对照组患者给予盐酸二甲双胍片0.5 g,口服,每日3次;观察组患者在对照组治疗的基础上给予天芪降糖胶囊1.6 g,口服,每日3次。两组均用药4周。观察两组患者的临床疗效,治疗前后中医证候总积分、血糖水平[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)]、血脂水平[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、超敏C反应蛋白(hs-CRP)和内皮素-1(ET-1)水平、血液流变学指标、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]及不良反应发生情况。结果:观察组患者总有效率显著高于对照组(89.58%vs.70.83%),差异有统计学意义(P<0.05)。治疗后,两组患者中医证候总积分和血糖、hs-CRP、ET-1、TC、TG、LDL-C、血液流变学指标、MDA水平均显著低于同组治疗前,且观察组中医证候总积分、FPG、2 h PG、hs-CRP、ET-1、TC、TG、LDL-C、血液流变学指标、MDA水平均显著低于对照组;两组患者SOD水平均显著高于同组治疗前,且观察组显著高于对照组,同时观察组HDL-C水平显著高于同组治疗前及对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的疗效显著,可降低血糖、血脂水平,改善机体血液流变学状态及氧化应激反应,且安全性较好。OBJECTIVE： To observe clinical efficacy and safety of Tianqi jiangtang capsules combined with metformin in the treatment of elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions. METHODS： A total of 96 elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions were randomly divided into control group （48 cases） and observation group （48 cases）. Control group was given Metformin hydrochloride tablets 0.5 g orally, 3 times a day. Observation group was additionally given Tianqi jiangtang capsules 1.6 g orally, 3 times a day, on the basis of control group. Both groups received treatment for 4 weeks. Clinical efficacies of 2 groups were observed as well as total score of TCM symptoms, the levels of btood glucose （FPG, 2 hPG, HbA^c）, blood lipid （TC, TG, HDL-C, LDL-C）,hs-CRP, ET-1, blood rheology and oxidative stress indexes （MDA, SOD）, the occurrence of ADR. RESULTS： The total response rate of observation group was significantly higher than that of control group（89.58% vs. 70.83% ）, with statistical significance （P〈0.05）. After treat- ment, total score of TCM symptoms, the levels of blood glucose, hs-CRP, ET-1, TC, TG, LDL-C, blood rheology indexes and MDA in 2 groups were significantly lower than before; total score of TCM symptoms, the levels of FPG, 2 hPG, hs-CRP, ET-1, TC, TG, LDL-C, blood rheology indexes and MDA in observation group were significantly lower than control group; the level of SOD in 2 groups were significantly higher than before, and the observation group was significantly higher than control group, and the level of HDL-C in observation group was significantly higher than before treatment and control group, with statistical signifi- cance （P〈0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Tianqi jiangtang capsules combined with metformin show significant therapeutic efficacy in the treatment of elderly patients with type 2 diabetes mellitus, and can red

关 键 词：2型糖尿病 脑微血管病变 天芪降糖胶囊 二甲双胍 疗效 安全性 

分 类 号：R587.1[医药卫生—内分泌]