阿苯达唑治疗囊型棘球蚴病疗效的Meta分析  

Therapeutic Efficacy of Albendazole in the Treatment of Cystic Echinococcosis:A Meta-analysis

作　　者：索朗央宗[1,2,3,4,5] 张伶俐[2,3,4] 泽碧[5] 蒋璐灿 归舸 白玛央宗[5] 兰珍[6] 

机构地区：[1]四川大学华西药学院,成都610041 [2]四川大学华西第二医院药学部,成都610041 [3]四川大学华西第二医院循证药学中心,成都610041 [4]出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [5]西藏自治区人民医院药剂科,拉萨850000 [6]西藏自治区人民医院妇产科,拉萨850000

出　　处：《中国药房》2017年第15期2069-2072,共4页China Pharmacy

基　　金：国家科技支撑计划课题(No.2009BAI76B030920)

摘　　要：目的:系统评价阿苯达唑治疗囊型棘球蚴病的疗效,为临床提供循证参考。方法:计算机检索Pub Med、EMBase、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库,收集阿苯达唑单药或联合其他阳性药物/外科手术治疗囊型棘球蚴病的随机对照试验(RCT),对符合纳入标准的研究提取资料并按照Cochrane协作网提供的偏倚风险评价工具5.1.0进行质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入11项RCT,合计1 020例患者。Meta分析结果显示,阿苯达唑单药治疗囊型棘球蚴病可以显著提高有效率[RR=4.08,95%CI(1.82,9.14),P<0.001];阿苯达唑联合其他阳性药物的有效率显著高于阳性药物单用[RR=1.28,95%CI(1.01,1.63),P=0.04];阿苯达唑联合外科手术治疗的有效率显著高于单纯外科手术治疗[RR=1.22,95%CI(1.10,1.35),P<0.001],差异均有统计学意义。结论:阿苯达唑单药或联合其他阳性药物/外科手术治疗囊型棘球蚴病疗效均较好。OBJECTIVE： To systematically review therapeutic efficacy of albendazole in the treatment of cystic echinococcosis, and to provide evidence-based reference for clinic treatment. METHODS： Retrieved from PubMed, EMBase, Cochrane library, CBM, CJFD, VIP and Wanfang database, randomized controlled trails（RCTs） about albendazole alone or combined with other positive drugs/surgery in the treatment of cystic echinococcosis were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation according to Cochrane bias risk evaluation tool 5.1.0. RESULTS： A to- tal of 11 RCTs were enrolled, involving 1 020 patients. Results of Meta-analysis showed the response rate of albendazole alone was significantly higher than that of placebo in the treatment of cystic echinococcosis [RR=4.08,95% CI （1.82,9.14）, P〈0.001]; re- sponse rate of albendazole＋other positive drugs was significantly higher than that of positive drug alone in the treatment of cystic echinococcosis [RR= 1.28,95 % CI （ 1.01,1.63）, P=- 0.04]; response rate of albendazole＋surgery was significantly higher that that of surgery alone in the [RR= 1.22,95% CI（ 1.10, 1.35）,P〈0.001]; there was statistical significance. CONCLUSIONS： Both albendazole alone or combined with other positive drugs/surgery show good therapeutic efficacy in the treatment of cystic echinococcosis.

关 键 词：阿苯达唑 囊型棘球蚴病 疗效 系统评价 

分 类 号：R979.8[医药卫生—药品]