炎琥宁注射剂治疗流行性腮腺炎疗效的循证评价  

Evidence-based Review on Yanhuning Injection in the Treatment of Epidemic Mumps

作　　者：田波[1] 胡建新[1] 胡瑞钺[1] 李志优[1] 

机构地区：[1]江西省人民医院药剂科,南昌330006

出　　处：《中国药房》2017年第15期2077-2081,共5页China Pharmacy

基　　金：江西省卫生计生委科技计划项目(No.20151013)

摘　　要：目的:系统评价炎琥宁注射剂治疗流行性腮腺炎的疗效,探索省增补基本药物循证评价的有效方式,为新版基本药物目录遴选提供参考。方法:计算机检索Pub Med、中国期刊全文数据库(CJFD)、万方数据库、中文科技期刊数据库(VIP),收集炎琥宁注射剂单用或者联合其他阳性药物(试验组)对比其他阳性药物(对照组)治疗流行性腮腺炎的随机对照试验(RCT),采用改良的Jadad评分量表评价质量后,提取有效数据采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入26项RCT,合计2 613例患者。Meta分析结果显示,试验组患者总有效率[OR=5.28,95%CI(3.92,7.11),P<0.001]显著高于对照组,退热时间[MD=-1.97,95%CI(-2.83,-1.12),P<0.001]、肿胀消退时间[MD=-2.05,95%CI(-2.53,-1.58),P<0.001]、疼痛消失时间[MD=-1.39,95%CI(-2.02,-0.75),P<0.001]均显著短于对照组,差异均有统计学意义。结论:炎琥宁注射剂治疗流行性腮腺炎疗效较好,可显著缩短患者退热时间、肿胀消退时间和疼痛消失时间。OBJECTIVE： To systematically evaluate therapeutic efficacy of Yanhuning injection in the treatment of epidemic mumps, explore valid way of evidence-based review, provide reference for the selection of new essential medicine list. METH- ODS： Retrieved from PubMed, CJFD, Wanfang database and VIP, randomized controlled trials （RCTs） about Yanhuning injection alone or combined with other positive drugs （trial group） vs. other positive drugs （control group） in the treatment of epidemic mumps. Meta-analysis was conducted by using Rev Man 5.3 statistical software after quality evaluation by modified Jadad scale. RE- SULTS： Totally 26 RCTs were included, involving 2 613 patients. Results of Meta-analysis showed, overall response rate [OR= 5.28,95 % CI （3.92,7.11 ）, P〈 0.001] of trial group was significantly higher than that of control group; defervescence time [MD = -- 1.97,95 % CI （ -- 2.83, -- 1.12 ）, P〈 0.001 ], swelling disappearance time [MD ---- -- 2.05,95 % CI （ -- 2.53, -- 1.58 ）, P〈 0.001] and pain disappearance time [MD = -- 1.39,95 % CI （ -- 2.02, -- 0.75）, P〈 0.001] of trial group were significantly shorter than those of control group, there was statistical significance. CONCLUSIONS： Yanhuning injection has good curative effect for epidemic mumps, and can significantly shorten defervescence time, swelling disappearance time and pain disappearance time.

关 键 词：基本药物 增补 循证评价 炎琥宁注射剂 流行性腮腺炎 META分析 疗效 

分 类 号：R373.16[医药卫生—病原生物学] R512.1[医药卫生—基础医学]