结核感染T细胞斑点试验在老年肺结核诊断中的价值  

Value of T-SPOT. TB for the Diagnosis of Tuberculosis in Elderly Patients

作　　者：孙贝贝[1] 赵丽敏[1] 马利军[1] 况红艳[1] 曹帆[1] 

机构地区：[1]河南省人民医院(郑州大学人民医院)呼吸与危重症医学科,河南省郑州市450003

出　　处：《中国全科医学》2017年第15期1884-1887,共4页Chinese General Practice

基　　金：2015年河南省重点科技攻关计划项目(152102310147);2015年河南省科技厅国际合作项目(134300510020)

摘　　要：目的探讨结核感染T细胞斑点试验(T-SPOT.TB)对老年肺结核的临床诊断价值。方法选取2013年2月—2014年2月于河南省人民医院住院或门诊确诊的活动性肺结核患者140例为研究对象。按年龄将患者分为老年组(年龄≥60岁,n=68)和青壮年组(年龄<60岁,n=72)。两组患者均行外周血T-SPOT.TB及结核菌素皮肤试验(TST),并分析其结果。结果两组患者T-SPOT.TB结果比较,差异无统计学意义(P>0.05);老年组患者TST阳性率低于青壮年组(P<0.05)。青壮年组、老年组患者T-SPOT.TB阳性率均高于TST阳性率(P<0.05)。结论T-SPOT.TB作为一种新的诊断技术,在老年肺结核的临床诊断中具有较好的应用价值。Objective To investigate the value of T-SPOT.TB for the diagnosis of tuberculosis in elderly patients.Methods The participants recruited were 140 outpatients and inpatients with tuberculosis diagnosed in Henan Provincial People′s Hospital between February 2013 and February 2014.In accordance with the age,they were divided into the elderly group（≥60 years old,n=68）,and the young and middle-aged group（〈60 years old,n=72）.Both groups underwent T-SPOT.TB and tuberculin skin test（TST）,and the testing results of them were compared.Results There was no significant difference in the positive rate of T-SPOT.TB between the elderly and the young and middle-aged patients（P〉0.05）.The positive rate of TST in the elderly group was lower than that in the young and middle-aged group（P〈0.05）.The positive rate of T-SPOT.TB was higher than that of TST in both groups（P〈0.05）.Conclusion As a new diagnostic technique,T-SPOT.TB has a good application value in the clinical diagnosis of tuberculosis in elderly patients.

关 键 词：结核 肺 老年人 结核菌素试验 结核感染T细胞斑点试验 

分 类 号：R521[医药卫生—内科学]