某区妇幼保健院345例药品不良反应报告的相关因素分析  

Analysis on Related Factors of Adverse Drug Reactions of Reporting 345 Cases in A District Hospital of Maternal and Children Health Care

作　　者：钟明[1] 陈瑜[1] 吴立明[1] 郭惠娟[1] 

机构地区：[1]深圳市宝安区妇幼保健院,广东深圳518133

出　　处：《抗感染药学》2017年第2期341-343,共3页Anti-infection Pharmacy

摘　　要：目的:分析妇幼保健院药品不良反应报告的相关因素,为安全用药提供参考。方法:选择2014年4月—2016年4月间上报的345例药品不良反应报告,采用回顾性分析法,分析引起药品不良反应患者年龄以及涉及的药物类别、给药途径、累及器官等因素。结果:345例药品不良反应报告中,年龄段在18~40岁患者占41.45%显著高于其他年龄段患者;药物类别中抗感染药物占36.52%显著高于其他类别药物;心血管系统药物、神经系统药物构成比分别占13.91%和10.14%,仅次于抗感染药物;给药途径中,静脉滴注占55.65%显著高于其他给药途径;口服给药占26.38%仅次于静脉滴注;累及消化系统占56.52%显著高于其他脏器和系统,累及心血管系统占24.93%仅次于消化系统。结论:对药品不良反应报告予以全面分析,医院药品不良反应的发生存在一定规律与特征,可为临床合理用药提供有效指导,从而提高治疗安全性。Objective： To analyze the adverse drug reaction reports in Maternal and Child Health Care Hospital and to provide a reference for safe medication. Methods： 345 cases of adverse drug reactions were retrospectively analyzed from April 2014 to April 2016, and gender and age of patients with adverse drug reactions and the drug category, route of administration and organ involved were statistically analyzed by retrospective analysis. Results： In the report of 345 cases of patients with adverse medicine reactions, ages were between 18 and 40, （the composition ratio of patients was 41.45%）, significantly higher than other age groups. The constituent ratio of anti-infective drugs was 36.52% in medi- cine classes, which was significantly higher than other categories of drugs. In cardiovascular drugs; nervous system drugs accounted ~br 13.91% and 10.14%, which was only second to anti-infective drugs. In the route of administration, the constituent ratio of intravenous drip was 55.65%, which was significantly higher than other routes of administration. Oral ratio was 26.38%, which was only second to intravenous drip and the proportion of digestive system was 56.52%, which was significantly higher than that of other organ system. The constituent ratio was 24.93% in the involved cardio- vascular system, which was only second to the digestive system. Conclusion： By comprehensive analysis of adverse drug reaction reports, there are certain laws and characteristics of adverse drug reactions in hospital, which can provide effective guidance for clinical rational drug use so as to improve the safety of treatment.

关 键 词：药品不良反应 合理用药 抗菌药物 给药途径 

分 类 号：R969.3[医药卫生—药理学]