229例患者中药注射剂致过敏性休克原因的循证分析  

Evidenced-based Analysis in 229 Patients of Anaphylactic Shock Caused by Traditional Chinese Medicine Injections

作　　者：蔡丽娟[1] 邓英光[1] 周燕芬[2] 

机构地区：[1]广州市第十二人民医院,广州511400 [2]广州医学院附属第一医院,广州511400

出　　处：《抗感染药学》2017年第2期344-347,共4页Anti-infection Pharmacy

摘　　要：目的:分析中药注射剂致过敏性休克的原因和特点,为临床合理用药提供参考。方法:检索中国知网《中国期刊全文数据库》中相关中药注射剂致过敏性休克的报道,分析和归纳就诊医院、诊断、过敏史、用法用量、联合用药情况、发生时间、抢救措施、转归情况等方面。结果:229例中药注射剂致过敏性休克的病例中,发生过敏性休克病例最多的是清开灵注射液88例;多数过敏性休克发生在用药后30 min内,基层医疗机构发生过敏性休克患者的病死率为最较高。结论:中药注射剂成分复杂,容易导致过敏性休克的发生,联合多药使用增加不良反应的风险,临床应加强用药过程中的监测,切实做到中药注射液的合理用药。To analyze the reasons and characteristics of anaphylactic shock induced by Traditional Chinese Medi- cine（TCM） injection and to provide reference for clinical rational drug use. Methods： The domestic reports of anaphy- lactic shock from ＂Chinese Journal Full-text Database＂ in CNKI were retrieved and analyzed in respect of the hospital, diagnosis, allergic history, dosage, application method, drug combination, occurrence time, first-aid measures, regres- sion, etc. Results ： Among the 229 cases of anaphylactic shock, most cases of anaphylactic shock were induced by Qin- gkailing injection, a total of 88 cases; most of the anaphylactic shock occurred within 30 minutes after injection, the ana- phylactic shock patients in grassroots medical institutions with high fatality rate. Conclusion： TCM injection composi- tion is complicated, it is easy to cause the occurrence of anaphylactic shock and drug combinations increase the risk of adverse reactions. The process of drug use should be strictly monitored in order to reduce the incidence of anaphylactic shock caused by TCM injection ensuring the rational drug use.

关 键 词：中药注射剂 过敏性休克 循证分析 

分 类 号：R969.3[医药卫生—药理学]