抗病毒合剂与奥司他韦联用对流行性感冒患儿的临床疗效评价  

Clinical Efficacy of Anti-virus Mixture Combined with Oseltamivir in Children Patients with Influenza

作　　者：柳石磊 马伏英[1] 

机构地区：[1]武警总医院感染疾病科,北京100039

出　　处：《抗感染药学》2017年第2期361-363,共3页Anti-infection Pharmacy

摘　　要：目的:评价抗病毒合剂与奥司他韦联用对流行性感冒患儿的临床疗效。方法:采用回顾性分析法,选取2015年6月—2016年4月期间收治的流行性感冒患儿80例的临床资料,采用随机数字表法将患儿分为观察组40例和对照组40例;对照组患儿给予奥司他韦治疗,观察组患儿在对照组基础上加用抗病毒合剂治疗,比较两组患儿治疗后的总有效率和不良反应的发生率。结果:观察组患儿治疗后的总有效率为95.00%高于对照组为80.00%(P<0.05),体温复常时间、鼻塞流涕好转时间、治疗时间以及咽红肿痛复常时间均优于对照组(P<0.05),不良反应的发生率为7.5%低于对照组为30.0%(P<0.05)。结论:采用抗病毒合剂与奥司他韦联用治疗小儿流行性感冒患儿,临床疗效较为显著,不良反应较低,有利于患儿的康复。Objective： To evaluate the clinical efficacy of anti-virus mixture combined with oseltamivir in children patients with influenza. Methods： In a retrospective analysis of clinical data, 80 cases of influenza in children were se- lected from June 2015 to April 2016 using the random data list method： the children were divided into observation group （40 cases） and control group （40 cases）; the control group were given oseltamivir treatment, observation in the controp group based on treatment in the contrpl group with antiviral agents, and the incidence rate of total effective rate and adverse reaction were compared between the two groups after treatment. Results： The effective rate of the treat- ment group was 95.00% significantly higher than 80.00% of the control group treatment effective rate was statistically significant（P〈0.05）; in the observation group the body temperature recovery time, recovery time and treatment time of the congestion and swelling erythrogullet recovery time was significantly shorter than the control group, and had statisti- cal significance（P〈0.05）; in observe groups, the adverse reaction rate was 7.50%, lower than the control group in which the adverse reaction rate was 30.00%, the rate of adverse reactions between the two groups were significantly different （P〈0.05） and had statistical significance. Conclusion： Patients in Children in children with influenza were treated by using antiviral agent combined with oseltamivir and clinical efficacy is significant higher, and adverse reaction is low- er, which is beneficial to the patient＇s recovery.

关 键 词：抗病毒合剂 奥司他韦 流行性感冒 临床疗效 

分 类 号：R969.3[医药卫生—药理学]