甲强龙治疗小儿难治性支原体肺炎及对痰液相关细胞因子的影响分析  

Effect analysis of methylprednisolone on refractory mycoplasma pneumonia in children and its effect on sputum-related cytokines

作　　者：王启芝[1] 周江颖 葛群波 沈洁娜 方晓燕[1] 

机构地区：[1]浙江省慈溪市妇幼保健院儿科,浙江慈溪315300

出　　处：《中国现代医生》2017年第13期58-60,64,共4页China Modern Doctor

摘　　要：目的分析甲强龙治疗小儿难治性支原体肺炎及对痰液相关细胞因子的影响。方法将2014年7月~2016年10月期间我院儿科收治的110例难治性支原体肺炎的患儿纳入研究,采用随机数字表法分为观察组和对照组,对照组接受常规治疗,观察组接受甲强龙治疗,分析治疗疗效及痰液相关因子水平变化。结果观察组总有效率为92.73%,高于对照组(76.36%)(χ2=5.636,P<0.05)。观察组体温恢复正常、咳嗽消失、肺部啰音消失和肺部阴影消失时间均短于对照组(t=16.369、15.095、15.677、10.381,P均<0.05)。经治疗,观察组痰液中白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-ɑ)和白细胞介素-2(IL-2)水平均低于对照组(t=10.772、14.970、8.546、9.034,P均<0.05)。结论甲强龙对小儿难治性支原体肺炎有较好的治疗效果,可缩短相关症状持续时间,并降低痰液中炎症因子水平。Objective To analyze the effect of methylprednisolone on refractory mycoplasma pneumonia in children and its effect on sputum-related cytokines. Methods A total of 110 children with refractory mycoplasma pneumonia in the Department of Pediatrics from July 2014 to October 2016 were enrolled in this study. The children were divided into observation group and control group according to random numbers method. The control group received conventional treatment, and the observation group received methylprednisolone treatment. The treatment efficacy and changes in the level of sputum-related factors between the two groups were analyzed. Results The total effective rate was 92.73% in the observation group, which was higher than 76.36% in the control group（χ^2=5.636, P〈0.05）. The time of body temperature returning to normal, cough, lung rales and lung shadow disappearing in the observation group were shorter than those in the control group （t=16.369, 15.095, 15.677, 10.381, P〈0.05）. Interleukin-4 （IL-4）, interferon-α（IFN-α）, tumor necrosis factor-α （TNF-α） and interleukin-2 （IL-2） in the sputum of the observation group were lower than those of the control group （t=10.772, 14.970, 8.546, 9.034, P〈0.05）. Conclusion Methylprednisolone has a good therapeutic effect on children with refractory mycoplasma pneumonia, which can shorten the duration of related symptoms and reduce the level of inflammatory factors in sputum.

关 键 词：甲强龙 儿童 难治性支原体肺炎 痰液 炎症因子 

分 类 号：R725.6[医药卫生—儿科]