Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion  

作　　者：Wu, Han Zhou, Xu Fu, Gong-Bo He, Zhi-Ying Wu, Hong-Ping You, Pu Ashton, Charles Wang, Xin Wang, Hong-Yang Yan, He-Xin[1,2] 

机构地区：[1]Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China [2]Natl Ctr Liver Canc, Shanghai 200438, Peoples R China [3]Second Mil Med Univ, Dept Cell Biol, Shanghai 200433, Peoples R China [4]Naval Med Res Inst, Shanghai 200433, Peoples R China [5]Univ Southern Calif, Zilkha Neurogenet Inst, Los Angeles, CA 90033 USA [6]Inner Mongolia Univ, Key Lab, Natl Educ Minist Mammalian Reprod Biol & Biotechn, Hohhot 010070, Inner Mongolia, Peoples R China

出　　处：《Cell Research》2017年第5期709-712,共4页细胞研究（英文版）

摘　　要：Dear Editor, Liver exhibits robust regeneration following mechan- ical damage due to immediate proliferation of hepato- cytes. It has been recently reported that hepatocyte re- plenishment following liver damage could also occur via a reversible transition between hepatocytes and duct-like progenitor cells [1]. Hepatocyte-derived duct-like pro- genitor cells were observed to expand extensively in the presence of toxic insults and re-differentiate into func- tional hepatocytes upon cessation of injury [1].

分 类 号：Q[生物学]