纳米壳聚糖碘的制备研究  

Study on Preparation of Nano Chitosan-iodine

作　　者：熊英[1] 王兴浩[1] 刘文迎 张静[1] 

机构地区：[1]郑州大学化工与能源学院,河南郑州450001

出　　处：《广州化工》2017年第10期36-38,共3页GuangZhou Chemical Industry

基　　金：新型纳米氧化再生纤维素-壳聚糖复合止血材料的构建与性能研究;高等学校重点科研项目(17A530004)

摘　　要：用正交设计的方法,考察了反应的温度和时间等对壳聚糖碘溶解度的影响。使用红外和粒径分析对壳聚糖碘进行了表征,并使用紫外分析了超声对产物溶解度的影响。通过对实验结果的分析,结合经济性考虑,得到最优的反应条件:反应温度5℃,反应时间3 h,超声后壳聚糖碘的溶解度由原来的0.49 mg/mL提升到8.1 mg/mL。在该最优级工艺下,纳米壳聚糖碘得率最高,纳米微粒均匀,已达到相对最优条件。The effects of reaction temperature and time were investigated with the method of orthogonal design. Thesolubility of chitosan iodine using infrared and particle size analysis of iodine chitosan were characterized by UV, and theeffect of ultrasound on solubility was analyzed. By analyzing the experimental results and considering the economicalefficiency, the optimum reaction conditions were studied ： reaction temperature was 5 ℃, reaction time was 3 h, ultrasonicsolubility of chitosan-iodine was from 0.49 mg/mL to 8. 1 mg/mL. Atthe optimal process, the nano chitosan-iodinenanoparticles had the highest yield and the nanoparticles were uniform, it reached a relatively optimal condition.

关 键 词：纳米 壳聚糖 碘 溶解度 

分 类 号：TQ46[化学工程—制药化工]