双臂钳联合尼龙绳技术闭合急性胃穿孔可行性及初步疗效的动物实验研究  

A primary study of endoscopic dosure of acute gastric perforation using twin grasper combined with endoloops in a porcine survival model

作　　者：董芳芬 何颖颖[1] 陈予真 林楷 宋泽宇[1] 许亮亮[1] 谢招飞[3] 施宏[3] 

机构地区：[1]福建医科大学医学技术与工程学院,福州350004 [2]福州市第七医院外科 [3]福建医科大学附属肿瘤医院内镜室

出　　处：《中华消化内镜杂志》2017年第5期354-357,共4页Chinese Journal of Digestive Endoscopy

基　　金：福建医科大学大学生创新创业训练计划项目（C1503）

摘　　要：目的初步探讨钳式双臂抓取器（简称双臂钳）联合尼龙绳技术闭合急性胃穿孔的可行性及疗效。方法实验猪2只，在双孔道内镜下应用双臂钳联合尼龙绳技术闭合急性胃穿孔，术后观察存活情况，后解剖观察穿孔部位的闭合情况。结果实验术后观察1周，期间有轻度感染，1周后剖腹检查发现腹腔轻度粘连，穿孔部位尼龙绳脱落，可见溃疡样缺损，亚甲蓝测漏试验阴性，组织学检查见肉芽组织连接胃穿孔部位，有慢性炎细胞浸润及纤维组织增生，再生黏膜向穿孔中心爬行。结论双臂钳联合尼龙绳闭合急性胃穿孔技术可行，疗效确切。Objective To evaluate the feasibility and efficacy of twin grasper combined with endoloops on closing acute stomach perforation. Methods Two experimental porcines of stomach perforation underwent endoscopic closure by twin grasper combined with endoloops. Survival conditions and closure of perforating were observed. Results Mild infection and abdominal adhesions were observed in one week after operation. The nylon rope fell off and an ulcer-like lesion was presented in the closed position. The methylene blue leak test was negative. Histologic examination revealed chronic inflammatory cells infiltration, granulation, fibroplasias, and regenerative mucous membrane crawling toward the center of perforation. Conclusion The technique of twin grasper combined with nylon ropes in closing the acute stomach perforation is feasible and effective.

关 键 词：胃穿孔 动物实验 双臂钳 尼龙绳 

分 类 号：R656.6[医药卫生—外科学]