127例HIV/AIDS患者抗病毒治疗1年CD4^+T淋巴细胞结果  

CD4^+ T lymphocyte numbers after one year's highly active antiretroviral therapy among 127 HIV/AIDS persons

作　　者：贾清[1] 马韶辉[1] 汪春翔[1] 吴建英[1] JIA Qing MA Shaohui WANG Chunxiang WU Jianying(Qinghai Center for Disease Control and Prevention, Xining, Qinhai 810007, China)

机构地区：[1]青海省疾病预防控制中心检验检测中心,青海西宁810007

出　　处：《中国热带医学》2017年第5期489-491,共3页China Tropical Medicine

摘　　要：目的分析HIV/AIDS患者抗病毒治疗前后CD4^+T淋巴细胞数的变化情况,为全省的抗病毒治疗提供科学依据。方法对青海省2013—2015年间接受抗病毒治疗的127名HIV/AIDS患者治疗前、治疗后3个月、6个月、9个月及12个月CD4^+T淋巴细胞数进行检测和统计学分析。结果 127例HIV/AIDS患者的平均开始治疗年龄为(37.6±10.8)岁,治疗前CD4^+T淋巴细胞数平均水平为(321.2±108.4)个/μL;患者治疗3个月、6个月、9个月和12个月时与进入治疗时点相比,其CD4^+T淋巴细胞数平均增加了52.2个/μL、75.8个/μL、75.3个/μL和76.5个/μL,差异均有统计学意义(P<0.01);经抗病毒治疗1年后,CD4^+T淋巴细胞数>500个/μL的患者从0例增至37例,占患者总数的29.1%;CD4^+T淋巴细胞数分为≤200个/μL、201~350个/μL和>350个/μL三组患者,经抗病毒治疗1年后,CD4^+T淋巴细胞数平均分别增加了80.7个/μL、84.7个/μL和65.8个/μL,不同组患者HAART治疗1年后CD4^+T淋巴细胞数均值变化差异有统计学意义(P均<0.05)。结论青海省目前的HAART治疗效果明显,同时提高HIV/AIDS患者的依从性,并尽早开展抗病毒治疗,有利于提高患者的生命质量,延缓疾病进程,降低病死率。Objective To understand the changes of CD4^＋T lymphocyte numbers among HIV-infected persons/AIDSpatients（HIV/AIDS persons） after the highly active antiretroviral therapy（HAART）, so as to provide the evidence for improvingHAART in Qinghai Province. Methods The CD4^＋T lymphocyte counts among 127 HIV/AID persons were detected andanalyzed before and after 3 months, 6 months, 9 months and 12 months＇ HAART in Qinghai Province from 2013 to 2015.Results The average age was（37.6±10.8） years and the average count of CD4^＋T lymphocytes was（321.2±108.4） cells/μLamong the 127 HIV/AID persons before HAART. Comparing with the lymphocyte counts before HAART, the average CD4^＋Tlymphocyte counts were increased with 52.2 cells/μL, 75.8 cells/μL, 75.3 cells/μL and 76.5 cells/μL respectively after 3months, 6 months, 9 months and 12 months＇ HAART with statistically significant differences（P0.01）. The persons whoseCD4^＋T lymphocyte counts were more than 500 cells/μL increased from zero to 37 cases with 29.1% of all the treated persons.These persons were grouped as CD4^＋T lymphocytes counts ≤ 200 cells/μL, 201-350 cells/μL and 350 cells/μL, and afterone year＇s HAART, the average CD4^＋T lymphocyte counts were increased with 80.7 cells/μL, 84.7 cells/μL and 65.8 cells/μLrespectively, with statistically significant differences（P〈0.05）. Conclusions The HAART is effective in Qinghai Provinceand it has higher compliance. The earlier antiretroviral therapy can effectively promote the life quality of the HIV/AIDSpersons, delay the course of HIV/AIDS, and reduce the mortality.

关 键 词：艾滋病 高效抗反转录病毒治疗 CD4^+T淋巴细胞 

分 类 号：R512.91[医药卫生—内科学]