双源CT双能量心肌首过灌注成像测量正常人左心室心肌碘含量的初步研究  

Determination of iodine content in the left ventricular myocardium of healthy subjects using dual-source dual-energy CT myocardial first perfusion imaging：a preliminary study

作　　者：陈梓娴[1] 王刚[1] 梁莉[1] 卢星如[1] 郭奇虹[1] 翟亚楠[1] 史小男[1] Chen Zixian Wang Gang Liang Li Lu Xingru Guo Qihong Zhai Yanan Shi Xiaonan(Department of Radiology, First Hospital of Lanzhou University, Lanzhou 730000, Chin)

机构地区：[1]兰州大学第一医院放射科,730000

出　　处：《中华心血管病杂志》2017年第5期415-418,共4页Chinese Journal of Cardiology

基　　金：甘肃省卫生行业科研计划项目（GSWSKY2016-34）

摘　　要：目的 应用第2代双源CT双能量心肌首过灌注成像,分析正常人左心室心肌碘含量的正常值及不同节段心肌碘含量的差异.方法 本研究为回顾性研究.在2016年1至6月于兰州大学第一医院常规体检行双源CT双能量心肌灌注成像的连续病例中,选取各心腔形态、比例正常,且双能量扫描和冠状动脉CT血管造影（CTA）诊断结果为阴性的体检者,排除肝肾功能异常以及心电图、心功能及心肌酶出现异常者.筛选出符合条件者共42名,其中38名图像质量满足诊断和测量者作为研究对象.采用Siemens Dual Energy-Heart PBV图像处理软件,按照美国心脏协会的标准心肌17分段法,分别测量不同节段左心室心肌和主动脉（左冠状动脉开口层面）的碘含量,并计算标化含碘值（nIC）.结果 入选健康体检者左心室心肌碘含量为3.1 ～7.8 mg/ml,心肌1～17各节段nIC值分别为0.28 ±0.06、0.31 ±0.07、0.30 ±0.07、0.30±0.04、0.28 ±0.04、0.29 ±0.05、0.29±0.01、0.30±0.07、0.31 ±0.07、0.27±0.06、0.28±0.08、0.28±0.07、0.29±0.08、0.31 ±0.07、0.27 ±0.06、0.29±0.06和0.21 ±0.07,其中第17节段nIC值最低,且与其他节段比较差异均有统计学意义（P均＜0.05）,其余各节段间差异均无统计学意义（P均＞0.05）.结论 本研究健康体检者左心室心肌碘含量3.1～7.8 mg/ml,其中以心尖部碘含量为最低.Objective To analyze the normal value of the iodine content in the left ventricular myocardium of healthy subjects and to observe if there is a segmental differences on iodine distribution by using the second generation dual-source dual-energy computed tomography myocardial first perfusion imaging.Methods In this retrospective study,42 healthy subjects,who admitted to our department between January to June 2016,with normal second generation dual-source dual-energy computed tomography and coronary CT angioghphy （CTA）,electrocardiogram （ECG） results,normal cardiac,hepatic,renal function,normal myocardial enzymes results were enrolled,data from 38 out of 42 subjects with satisfactory image quality were analyzed using Siemens Dual Energy-Heart PBV image processing software.In accordance with the standards of the American Heart Association myocardial 17 fractionation method,content of iodine was measured at different segmental left ventricular myocardium and aorta （left coronary artery from the opening level）.The standardized containing iodine value （nIC） was calculated.Results The iodine content of left ventricular myocardium in normal subjects was 3.1-7.8 mg/ml.The nIC of myocardium from 1 st to 17th segments was 0.28 ±0.06,0.31 ±0.07,0.30 ±0.07,0.30 ±0.04,0.28 ±0.04,0.29 ±0.05,0.29±0.01,0.30±0.07,0.31 ±0.07,0.27±0.06,0.28±0.08,0.28±0.07,0.29 ±0.08,0.31 ± 0.07,0.27 ±0.06,0.29 ±0.06 and 0.21 ±0.07,respectively.The nIC of the 17th segment was the lowest and was significantly lower than in other segments （all P ＜ 0.05）,the nIC was similar among the rest 16 segments （all P ＞ 0.05）.Conclusion The normal iodine content range in left ventricle myocardium is 3.1 -7.8 mg/ml,and the lowest iodine content is detected in the apex and which is significantly lower than the other left ventricular segments.

关 键 词：体层摄影术 X线计算机 心肌 碘 

分 类 号：R816.2[医药卫生—放射医学]