血β2-MG、CysC、SOD水平与冠状动脉血管病变的关系  

Relationship between serum levels of β2-MG, CysC, SOD and coronary lesions in patients with coronary heart disease

作　　者：卢小岚[1] 张晓[1] 朱记法[1] 邢军辉[1] 

机构地区：[1]郑州大学第一附属医院,450052

出　　处：《中国实用医刊》2017年第9期20-23,共4页Chinese Journal of Practical Medicine

基　　金：河南省高等学校重点科研项目（16A320027）

摘　　要：目的 探讨血β2微球蛋白（β2-MG）、胱抑素C（CysC）、超氧化物歧化酶（SOD）水平与冠状动脉血管病变的关系.方法 测定108例非冠心病患者和119例冠心病患者的血β2-MG、CysC、SOD水平,依冠状动脉造影结果行冠状动脉狭窄程度评分（Gensini评分）进行综合比较分析.结果 冠心病组血β2-MG、CysC水平显著高于非冠心病组,SOD水平显著低于非冠心病组.冠心病各亚组间比较,血β2-MG、CysC水平随冠状动脉病变支数的增多而升高;血SOD水平在各亚组间比较差异未见统计学意义（P〉0.05）.血β2-MG、CysC水平越高,冠状动脉狭窄程度评分越高;而血SOD水平越高,冠状动脉狭窄程度评分越低.结论 β2-MG、CysC与冠状动脉血管病变支数及狭窄程度密切相关,提示这些指标在预测冠心病患者血管病变严重程度、对冠心病危险分层有一定的意义.Objective To study the relationship between serum levels of β2-microglobulin（β2-MG）, Cystatin C（CysC）, Superoxyde dismutase（SOD）and coronary lesions in patients with coronary heart disease （CHD）.Methods The serum levels of β2-MG, CysC, SOD in 108 non-CHD patients and 119 CHD patients were measured.According to the results of coronary angiography, the levels of coronary artery stenosis were evaluated using the Gensini score.Results The levels of β2-MG and CysC in CHD group were significantly higher than those in non-CHD group, but the level of SOD in CHD group was significantly lower.Among different CHD subgroups, the levels of β2-MG and CysC were increasing according with the increasing numbers of coronary arteries with stenosis lesions, but the differences of SOD levels were not significant.The higher levels of β2-MG and CysC, the higher scores of coronary artery stenosis;However, the higher levels of SOD, the lower scores of coronary artery stenosis.Conclusions The levels of β2-MG and CysC are closely correlated with the numbers of coronary arteries with the stenosis lesions and the levels of coronary artery stenosis, indicating that these factors have some significance in predicting the severities of vascular lesions and the risk stratifications in CHD patients.

关 键 词：冠心病 Β2微球蛋白 胱抑素C 超氧化物歧化酶 

分 类 号：R541.4[医药卫生—心血管疾病]