喜炎平注射液对大叶性肺炎患儿血清炎性因子的影响及疗效观察  

Effect and curative effect observation of Xiyanping injection on serum inflammatory cytokines of lobar pneumonia children

作　　者：郝珉[1] 宋文[1] 

机构地区：[1]山东省枣庄市立医院儿科,277100

出　　处：《中国实用医刊》2017年第9期100-102,共3页Chinese Journal of Practical Medicine

摘　　要：目的 观察喜炎平注射液对大叶性肺炎患儿血清炎性因子的影响及治疗效果.方法 选取104例大叶性肺炎患儿,随机分为对照组和实验组,每组52例.所有患儿给予常规抗感染及对症治疗,实验组患儿在常规治疗的基础上加用喜炎平注射液治疗.比较两组患者治疗前后肿瘤坏死因子（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、高迁移率族蛋白B1（HMGB1）等血清炎性因子水平和临床疗效.结果 经过喜炎平注射液治疗后实验组患儿TNF-α、IL-6、IL-8、IL-10、HMGB1等血清炎性因子水平显著低于对照组（P〈0.01）.实验组患儿发热持续时间、咳嗽缓解时间和肺部阴影吸收时间也均较对照组患儿显著缩短（P〈0.01）.结论 喜炎平注射液可显著降低大叶性肺炎患儿的血清炎性因子水平,改善其免疫功能,治疗效果确切.Objective To observe the effect and curative effect of Xiyanping injection on serum inflammatory cytokines of lobar pneumonia children.Methods The total of 104 children with lobar pneumonia were selected and randomly divided into control group and experiment group, with 52 cases in each group.All patients were given conventional anti-infection and symptomatic treatment, children in the experiment group were given Xiyanping injection additionally.The serum levels of TNF-α, IL-6, IL-8, IL-10 and HMGB1 in the two groups before and after treatment and the clinical curative effects were compared.Results After the treatment of Xiyanping injection, the serum levels of TNF-α, IL-6, IL-8, IL-10 and HMGB1 in the experiment group were significantly lower than those in the control group （P〈0.01）.The duration of fever, remission duration of cough and absorption time of lung shadow in the experiment group were significantly shorter than those in the control group （P〈0.01）.Conclusions Xiyanping injection can significantly reduce the serum levels of inflammatory factors of lobar pneumonia children and improve their immune function, and the effect is exact.

关 键 词：喜炎平 大叶性肺炎 肿瘤坏死因子-α 白细胞介素 高迁移率族蛋白B1 

分 类 号：R725.6[医药卫生—儿科]