2013-2015年抗菌药物使用和前五位病原菌检出率及耐药相关性分析  

Relevant analysis of antibacterial consumption with detectable rate and resistance in first top five pathogenic bacteria

作　　者：鞠永静[1] 

机构地区：[1]山东省临沂市沂水中心医院药学部,276400

出　　处：《中国实用医刊》2017年第9期120-123,共4页Chinese Journal of Practical Medicine

摘　　要：目的 分析住院患者抗菌药物使用与前五位病原菌检出率与耐药率之间的相关性,为临床合理应用抗菌药物提供参考.方法 按年调取医院2013-2015年抗菌药物使用人数、住院人数、住院人天数、抗菌药物使用量,前五位病原菌及其耐药率〈30%的抗菌药物,并计算各年度抗菌药物使用强度.结果 2013-2015年医院住院患者抗菌药物使用率分别是43.8%、42.1%和41.8%,使用强度分别是41.4、34.7和34.5 DDD.除金黄色葡萄球菌外,大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌和鲍曼不动杆菌检出率均逐年降低.2014年前五种细菌的检出率分别是1.72%、5.72%、4.07%、3.42%和1.08%.2013-2015年该五种细菌耐药率〈30%的抗菌药物种类稳定,均以β-内酰胺酶抑制剂复合制剂、头孢三代、头孢四代、碳青霉烯类、第三代喹诺酮和氨基糖苷类为主.结论 降低抗菌药物使用率和使用强度可以降低病原菌检出率,延缓细菌耐药产生.Objective To analyze relevance of antibacterial consumption with detectable rate and resistance in first top five pathogenic bacteria so as to provide basis for clinical rational use of antimicrobial drugs.Methods To obtain annual antimicrobial person, the number of inpatients and their length of stay, antimicrobial consumption, the first top five pathogenic bacteria and antibiotics whose resistance rate lower than 30 percent from 2013 to 2015, and calculated antimicrobial use density every year.Results From 2013 to 2015 antimicrobial use rate of inpatients was 43.8%, 42.1% and 41.8%, and their use density was 41.4, 34.7 and 34.5 DDD.Detectable rate of Escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae and baumanii was lower and lower year by year except staphylococcus aureus, and detectable rate of first five top pathogenic bacteria was 1.72%, 5.72%, 4.07%, 3.42% and 1.08% in 2015.Antimicrobial kinds whose resistance rate lower than 30 percent was stable including beta lactamase inhibitor compound preparation, third and fourth generation cephalosporin, carbapenems, third generation quinolone and aminoglycosides.Conclusions Reduction of antimicrobial use rate and density could cut down detectable rate of pathogenic bacteria and slow down bacterial drug resistance.

关 键 词：抗菌药物使用率 抗菌药物使用强度 检出率 耐药率 

分 类 号：R446.5[医药卫生—诊断学]