克林霉素耐药金黄色葡萄球菌检出率与抗菌药物使用的相关性分析  

Correlation between detection rate of clindamycin-resistant Staphylococcus aureus and utilization of antibacterial drugs

作　　者：蒋程[1] 吕健刚 李芳琼[1] 叶佐武[1] 鲁春芳[1] 李功华[1] JIANG Cheng LV Jiangang LI Fangqlong YE Zuowu LU Chunfang LI Gonghua(Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China Zhejiang Keland Information ＆ Technology Co. , Ltd. , Hangzhou 310022, Zhejiang, China)

机构地区：[1]浙江省立同德医院 [2]浙江科澜信息技术有限公司

出　　处：《中国临床药理学与治疗学》2017年第4期439-442,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省公益技术应用研究计划项目(2016C33127);浙江省中医药科技计划项目(2015ZQ007);浙江省药学会医院药学专项科研资助项目(2014ZYY10)

摘　　要：目的:建立基于偏最小二乘(PLS)回归算法的克林霉素耐药金黄色葡萄球菌(CRSA)检出率与抗菌药物使用相关性模型,为指导抗菌药物临床的合理使用提供依据。方法:以不同季度抗菌药物的用药频度(DDDs)为自变量,以同期和非同期CRSA的检出率为因变量,分别建立PLS回归模型,分析CRSA检出率比抗菌药物使用的滞后性。根据各变量的VIP值,筛选对CRSA检出率影响较显著的品种。结果:CRSA的检出率滞后于抗菌药物的使用2个季度,与头孢哌酮/舒巴坦、阿奇霉素、头孢呋辛的DDDs呈显著正相关。结论:PLS回归算法能同时分析CRSA检出率与多种抗菌药物使用的相关性,可为CRSA研究提供新的方法。AIM： To provide information for reasonable clinical application of antibacterial drugs, the partial least squares （PLS） regression models were established for analyzing the correlation be- tween detection rate of clindamycin-resistant Staphy- lococcus aureus （CRSA） and utilization of antibacte- rial drugs. METHODS： The PLS regression models were established with the defined daily doses （DDDs） of antibacterial drugs as independent varia- bles and the detection rates of CRSA with same and different periods as dependent variables. The lag between detection rates of CRSA and utilization of anti- bacterial drugs were investigated. The antibacterial drugs, which were highly correlated with the detec- tion rate of CRSA, were screened according to the variable importance （VIP） values. RESULTS ： The detection rate of CRSA lagged about two quarters behind the utilization of antibacterial drugs, and was significantly positively correlated with the DDDs of cefoperazone/sulbactam, azithromycin and cefu- roxime. CONCLUSION：It was effective to employ PLS regression algorithm to simultaneously analyze the correlation between detection rate of CRSA and utilization of multiple antibacterial drugs. This research provided a new scientific tool for the investi- gation of CRSA.

关 键 词：偏最小二乘回归 抗菌药物 用药频度 克林霉素耐药金黄色葡萄球菌 

分 类 号：R969[医药卫生—药理学]