角膜共聚焦显微镜对糖尿病周围神经病变的诊断价值  

Diagnostic value of corneal confocal microscopy on diabetic peripheral neuropathy

作　　者：刘颖丰 刘芳[1] Liu Yinfeng Liu Fang.(Department of Endocrinology ＆ Metabolism, Shanghai Jiaotong University Affiliated 6th People＇s Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, Chin)

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病临床医学中心,上海市重中之重代谢病临床医学中心,上海市糖尿病研究所,上海市糖尿病重点实验室,200233

出　　处：《国际内分泌代谢杂志》2017年第3期178-180,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81270397）;上海市科委医学与农业领域支撑计划（15411953100）

摘　　要：目前常用的糖尿病周围神经病变筛查与诊断手段无法做到客观准确以及鉴别高危人群.近年来一种新型检查手段——角膜共聚焦显微镜,可通过无创在体观察和准确定量检测角膜Aδ和C神经纤维的分支密度、长度、迂曲度等,精确诊断糖尿病周围神经病变,且临床研究证明其对糖尿病周围神经病变的早期筛查、预测具有肯定作用,值得在临床推广应用.Many instruments of diabetic peripheral neuropathy （DPN） are applied to screen and diagnose DPN,they all either fall into poor objectivity and accuracy,or can not be used to discriminate the high-risk population of DPN.As a newly invented technique,corneal confocal microscopy （CCM） diagnoses DPN precisely by measuring the branch density,fiber length and fiber tortuosity of A δ fibers and C fibers.Moreover,it is recently reported that CCM can predict and detect DPN early,which makes it feasible and profitable to apply in clinical practice.

关 键 词：角膜共聚焦显微镜 糖尿病周围神经病变 诊断 

分 类 号：R587.2[医药卫生—内分泌]