美洲大蠊化学成分及生物活性的研究进展  

Chemical Components and Biological Activities in Periplaneta America

作　　者：吕娜[1] 李广志[1] 王钧篪 沈连刚[1] 斯建勇[1] 

机构地区：[1]中国医学科学院药用植物研究所,北京100193

出　　处：《现代生物医学进展》2017年第16期3184-3190,共7页Progress in Modern Biomedicine

基　　金："十二五"国家科技重大创新药物专项(2011ZX09102-101-01;2012ZX09301-002-001)

摘　　要：美洲大蠊是源自西南民间的传统中药,目前市面已有"康复新液"、"心脉隆注射液"、"肝龙胶囊"和"消癥益肝片"四种相关成药在售。大量临床实践证明,其在抗炎消肿,保肝,组织修复,心肌保护方面有不错的疗效,但是其药理活性的物质基础和作用机制尚不明确,近年来已有不少学者致力于相关的系统研究,并且取得一些进展,从中获得了异黄酮、异香豆素等次生代谢物质,并且认为其机制是多因素,多细胞因子作用的结果。本文将上述的相关成果做了系统介绍,以期对未来美洲大蠊的研究有所帮助。Periplaneta America are the folk traditional medicine derived from southwest area. Until now there have been four related postmarketing drugs on sale-＂Kangfuxin Liquid＂, ＂Xinmailong Injection＂, ＂Ganlong Capsule＂ and ＂Xiaozheng Yigan Tablet＂. The modern studies show they have obvious effects on inflammation and tumefaction, wound surface, cardio-cerebrovascular diseases, Hepatitis B and liver cancer. But it＇s very little known about the active ingredients and mechanisms of action, this will significantly limit its usage in future. So, at present, many researchers are engaged in this field and make some progress by extracting secondary metabolites like isoflavones and isocoumarins from the crude materials. Also some of them consider that the mechanism is the result of multiple factors and cytokines. This review outlines recent advances of Periplaneta America in related aspects and is expected to provide a support to the thorough research of Periplaneta Amen＇ca.

关 键 词：美洲大蠊 化学成分 生物活性 抗纤维化 组织修复 

分 类 号：R932[医药卫生—生药学] R285[医药卫生—药学]