肠神经胶质细胞与体外循环致肠损伤相关性的研究进展  

Research Progress in the Relationship between Enteric Glial Cells and Intestinal Barrier Injury induced by Cardiopulmonary Bypass

作　　者：伊小婷[1,2] 陈克研[1] 周锦[1] 张铁铮[1] 孙莹杰[1] 

机构地区：[1]沈阳军区总医院麻醉科,辽宁沈阳110016 [2]大连医科大学研究生院,辽宁大连116044

出　　处：《现代生物医学进展》2017年第16期3191-3194,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81471121)

摘　　要：近年来,体外循环术后所引起的肠道功能改变及反映肠损伤的相关炎性介质变化越来越受到人们的关注。当肠屏障发生损害时,将会导致肠道内细菌移位、大量毒素及炎性因子释放,产生系统性炎症反应,进而引起脑、肺、肝、肾等多脏器功能衰竭。肠神经胶质细胞(EGCs)作为肠神经系统的重要组成部分,具有保护肠屏障功能及调节肠神经系统活动的作用。基础研究已证实,肠神经胶质细胞可作为肠屏障功能保护的相应靶点,通过激活EGCs的α7n Ach R来减轻肠屏障损伤所致的炎性反应。本文通过对近年体外循环所致肠屏障功能损伤机制和肠神经胶质细胞特点及其相关性的研究进展作一综述,从而为临床寻求防治肠损伤措施提供理论依据。In recent years, more and more people pay attention to the changes of intestinal function after cardiopulmonary bypass and the related inflammatory mediators of intestinal damage. When the intestinal barrier function dysfunction, it will lead to the displacement of intestinal flora and toxin, the release of a large number of pro-inflammatory factors, resulting in systemic inflammatory response, and then cause brain, lung, liver, kidney and other organs dysfunction. Enteric glial cells （EGCs）, an important component of the enteric nervous system, have the function of maintaining the intestinal barrier function and regulating the activities of enteric nervous system. Basic research has confirmed that enteric glial cells can be used as the corresponding target to protect intestinal barrier fimction, and reduce the inflammatory response induced by intestinal barrier damage by activating et7nAchR of EGCs. The research advances in the correlation of the mechanism of intestinal barrier dysfunction induced by cardiopulmonary bypass and the characteristics of enteric glial cells in recent years is reviewed in this article with the purpose of providing a theoretical basis for the prevention and treatment of intestinal injury.

关 键 词：肠神经胶质细胞 et7nAchR 体外循环 肠屏障 炎症 

分 类 号：R654[医药卫生—外科学]