经皮锁定钢板内固定治疗胫骨骨折的疗效及对患者血清IGF-1,TGF-β1及BGP水平的影响  

Clinical Effect of Percutaneous Locking Plate Fixation on Treatment of Tibial Fracture and Serum Levels of IGF-1, TGF-β1 and BGP in Patients

作　　者：李育刚[1] 许泽川[1] 常山[1] 曾智谋[1] 杨红胜[1] 

机构地区：[1]成都医学院第一附属医院骨科二区,四川成都610500

出　　处：《现代生物医学进展》2017年第17期3306-3309,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅科学研究基金项目(050229)

摘　　要：目的:探讨经皮锁定钢板内固定术对胫骨骨折的治疗效果及对患者术后功能的影响。方法:90例胫骨骨折患者参照抽签法分作对照组(n=45)和实验组(n=45),对照组采用切开复位解剖钢板内固定治疗,实验组采用经皮锁定钢板内固定术治疗。观察并比较两组患者治疗前后血清胰岛素样生长因子-l(IGF-1)转化生长因子-β1(TGF-β1)、骨钙素(BGP)水平,切口长度、术中失血量、住院时间、骨折愈合时间、临床疗效及并发症的发生率。结果:治疗后,实验组胰岛素样生长因子-l(IGF-1)转化生长因子-β1(TGF-β1)、骨钙素(BGP)高于对照组,差异具有统计学差异(P<0.05)。实验组切口长度、术中失血量、住院时间、骨折愈合时间少于对照组,差异具有统计学意义(P<0.05)。实验组优良率、康复率高于对照组,术后并发症发生率低于对照组,差异具有统计学意义(P<0.05)。结论:经皮锁定钢板内固定对胫骨骨折的治疗效果确切,可促进术后功能恢复。Objective： To research the clinical effect of percutaneous locking plate fixation on the treatment of tibial fracture and serum levels of IGF-1, TGF-β1 and BGP in patients. Methods： 90 patients with fracture tibia were divided into the control group （n=45） and the experimental group （n=45）. The patients in the control group were treated with open reduction and anatomical plate internal fixa- tion, while the patients in the experimental group were treated with percutaneous locking plate internal fixation. Then the serum levels of insulin-like growth factor-1 （IGF-1）, transforming growth factor-β1 （TGF-β1） and BGP （osteocalcin）, the incision length, intraoperative blood loss, hospitalization, fracture healing time, clinical curative effect and postoperative complications were observed and compared between the two groups before and after the treatment. Results： After treatment, the serum levels oflGF-1, TGF-β1 and BGP in the experimental group were higher than those of the control group, and the differences were statistically significant （P〈0.05）. The incision length, intraoperative blood loss, hospitaiization and fracture healing time of the experimental group were less than those of the control group, and the differences were statistically significant （P〈0.05）. The excellent and recovery rate of the experimental group was higher than that of the control group, and the differences were statistically significant （P〈0.05）. The postoperative complications of the experi- mental group was lower than that of the control group, and the differences were statistically significant （P〈0.05）. Conclusion： Percuta- neous locking plate fixation has obvious effect on the treatment oftibial fractures, which can increase the serum levels oflGF-1, TGF-β1 and BGP and promote the functional recovery of patients.

关 键 词：胫骨骨折 经皮锁定钢板内固定 胰岛素样生长因子-1(IGF-1) 转化生长因子-β1(TGF—β1) 骨钙素(BGP) 

分 类 号：R683[医药卫生—骨科学]