利奈唑胺治疗重症肺炎的疗效评价及对患者血清IL-1β,TGF-β和TNF-α水平的影响  

The Curative Effect of Linezolid on the Severe Pneumonia and the Influence on Serum IL-1β, TGF-β, TNF-α Levels

作　　者：陈慧冬[1] 詹枝华[1] 康亮[1] 雷华[1] 陈行珍 沈力[1] 罗伟昌[2] 

机构地区：[1]武汉市医疗救治中心呼吸病介入诊疗科,湖北武汉430070 [2]武汉大学附属中南医院呼吸科,湖北武汉430070

出　　处：《现代生物医学进展》2017年第17期3313-3316,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(13585MH52)

摘　　要：目的:分析利奈唑胺治疗重症肺炎患者的疗效及对血清炎症因子水平的影响。方法:收集2014年5月~2016年5月于我院就诊的104例重症肺炎患者,依据抽签法分作对照组(n=52)及观察组(n=52),对照组采用万古霉素治疗,观察组采用利奈唑胺治疗,观察组两组血清炎症因子(白细胞介素-1β(IL-1β)、转化生长因子-β(TGF-β)、肿瘤坏死因子-α(TNF-α))、血气分析指标(血氧饱和度(SaO_2)、氧分压(PaO_2)、氧合指数(PaO_2/FiO_2))、肺表面活性蛋白A(SP-A)、表面活性蛋白B(SP-B)、表面活性蛋白C(SP-C)、表面活性蛋白D(SP-D)、肺功能(最大呼气中段流量(MMF)、峰流速(PEF)、最大吸气压(Pimax)、最大呼气压(PEmax))疗效及安全性。结果:治疗后,观察组血清IL-1β、TNF-α、SP-A、SP-B、SP-C、SP-D均显著低于对照组,且观察组TGF-β、SaO_2、PaO_2、PaO_2/FiO_2、MMF、PEF、Pimax、PEmax明显高于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组(P<0.05),两组不良反应无统计学意义(P>0.05)。结论:利奈唑胺治疗重症肺炎患者的疗效确切,能够调节血清炎症因子的水平,恢复抗炎与促炎因子的动态平衡。Objective： To analyze the curative effect of linezolid on the severe pneumonia and its influence on the serum inflammatory factor levels. Methods： 104 cases of patients with severe pneumonia from May 2014 to May 2016 in our hospital were selected and divided into control group （n=52） and the observation group （n=52） according to the draw method. The control group was treated by vancomycin, while the observation group was treated by lmezolid, the serum inflammatory eytokines including interleukin-1β （IL-1β）, transforming growth factor-β（TGF-β）, tumor necrosis factor-α （TNF-α） levels, blood gas analysis index（blood oxygen saturation （SaO2）, oxygen partial pressure（PaO2）, oxygenation index （PaO2,/FiO2））, pulmonary surfactant protein（SP-A）, surfactant protein B（SP-B）, surfactant protein C（SP-C）, surfactant protein D（SP-D）, pulmonary function： maximum tidal midexpiratory flow （MMF）, peak velocity of flow （PEF）, maximal inspiratory pressure （Pimax）, maximum expiratory pressure （PEmax）, efficacy and safety. Results： After treatment, the serum IL-113, TNF-α, SP-A, SP-B, SP-C, SP-D of observation group were lower than those of the control group, the TGF-β, SaO2, PaO2, PaO2,FiO2, MMF, PEF, Pimax, PEmax of observation group were higher than those the control group （P〈0.05）. The total effective rate of observation group was higher than that of the control group （P〈0.05）. No statistical significance was found in the incidence of adverse re- actions between two groups （P〉0.05）. Conclusion： Linezolid was effective and equal to Linezolid in the treatment of patients with severe pneumonia, restore the anti-inflammatory and proinflammatory factor of dynamic balance.

关 键 词：利奈唑胺 重症肺炎 疗效 血清炎症因子 

分 类 号：R563.1[医药卫生—呼吸系统]