氯沙坦联合麝香保心丸治疗高血压并心衰患者的疗效分析  

Analysis of the Effect of Losartan plus Shexiang Baoxin Pill on Patients of Hypertension Combined with Heart Failure

作　　者：牛杰[1] 黎敬锋 王超[1] 李银[1] 朱章进 徐晓飞[1] 

机构地区：[1]安徽省滁州市第一人民医院心内科,安徽滁州239000

出　　处：《现代生物医学进展》2017年第17期3317-3319,3380,共4页Progress in Modern Biomedicine

摘　　要：目的:探究氯沙坦联合麝香保心丸治疗高血压合并心衰患者的临床效果。方法:选取我院于2014年1月~2016年1月收治的152例原发性高血压合并心力衰竭患者,按照治疗方法的不同随机分为观察组和对照组,每组76例。对照组患者予以吸氧、β受体阻滞剂、利尿等常规治疗,观察组在常规治疗的基础上加用氯沙坦联合麝香保心丸治疗,比较两组患者治疗前后的血压、心功能、血清血清B型脑钠肽(BNP)及超敏C反应蛋白(hs-CRP)水平。结果:治疗后,两组患者的血压、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、水平和血清BNP、hs-CRP水平均较治疗前显著降低(P<0.05),LVEF(%)水平较治疗前显著升高,且观察组患者的血压、LVEDD、LVESD水平和血清B型脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)水平显著低于对照组(P<0.05),LVEF(%)水平显著高于对照组(P<0.05)。结论:氯沙坦联合麝香保心丸治疗高血压合并心衰患者的临床效果优于常规治疗,可有效控制血压并改善患者的心功能。Objective： To explore the effect of Losartan plus Shexiang Baoxin pill on patients of hypertension combined with heart failure. Methods： 152 cases treated in our hospital t^om January, 2014 to January, 2016 were randomly divided into the observation and control group with each group of 76 cases. Control group received conventional therapy of oxygen inhalation, 13 receptor blocker, on the basis of which the observation group was given Losartan plus Sbexiang Baoxin pill. The blood pressure, heart function, level of BNP, hs-CRP were compared in both groups. Results： After therapy, the blood pressure, level of LVESD, LVEDD, BNP and hs-CRP in both groups were significantly decreased compared with those of before therapy （P〈0.05）, the level of LVEF （%） obviously increased compared with that of before therapy, and blood pressure, level of LVESD, LVEDD, BNP and hs-CRP in observation group were significantly lower than the control group （P〈0.05）; the level of LVEF（%） in observation group was significantly higher than control group （P〈0.05）; Conclusions： Losartan plus shexiangbaoxin pill has better clinical effect than conventional therapy in treating patients of hypertension combined with heart failure, which could effective improve cardiac function.

关 键 词：高血压 心力衰竭 氯沙坦 麝香保心丸 心功能 

分 类 号：R544.1[医药卫生—心血管疾病] R541.61[医药卫生—内科学]